Kartogenin stimulates chondrogenic differentiation of bone-derived mesenchymal stem cells (BMSCs) to improve repair of full-thickness cartilage defects in microfracture models. Kartogenin also induces formation of cartilage-like tissue and enhances wound healing in animal models. This compound may display pro-fibrotic activity. Kartogenin increases cartilage nodule formation, digit cartilaginous anlage elongation, synovial joint formation, and tendon maturation.
| Cas No. | 4727-31-5 |
|---|---|
| Purity | ≥98% |
| Formula | C20H15NO3 |
| Formula Wt. | 317.34 |
| IUPAC Name | 2-(4-Biphenylylcarbamoyl)benzoic acid |
| Solubility | DMSO 63 mg/mL Ethanol 5 mg/mL Water Insoluble |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Liu C, Ma X, Li T, et al. Kartogenin, transforming growth factor-β1 and bone morphogenetic protein-7 coordinately enhance lubricin accumulation in bone-derived mesenchymal stem cells. Cell Biol Int. 2015 Apr 9. [Epub ahead of print]. PMID: 25857705.
Xu X, Shi D, Shen Y, et al. Full-thickness cartilage defects are repaired via a microfracture technique and intraarticular injection of the small-molecule compound kartogenin. Arthritis Res Ther. 2015 Feb 2;17:20. PMID: 25641548.
Zhang J, Wang JH. Kartogenin induces cartilage-like tissue formation in tendon-bone junction. Bone Res. 2014;2. pii: 14008. PMID: 25419468.
Decker RS, Koyama E, Enomoto-Iwamoto M, et al. Mouse limb skeletal growth and synovial joint development are coordinately enhanced by Kartogenin. Dev Biol. 2014 Nov 15;395(2):255-67. PMID: 25238962.
