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Kartogenin

Kartogenin

Product ID K0271
Cas No. 4727-31-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $92.70 Please Inquire
25 mg $363.10 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Kartogenin stimulates chondrogenic differentiation of bone-derived mesenchymal stem cells (BMSCs) to improve repair of full-thickness cartilage defects in microfracture models. Kartogenin also induces formation of cartilage-like tissue and enhances wound healing in animal models. This compound may display pro-fibrotic activity. Kartogenin increases cartilage nodule formation, digit cartilaginous anlage elongation, synovial joint formation, and tendon maturation.

Product Info

Cas No.

4727-31-5

Purity

≥98%

Formula

C20H15NO3

Formula Wt.

317.34

Chemical Name

2-([1,1'-Biphenyl]-4-ylcarbamoyl)benzoic acid

IUPAC Name

2-(4-Biphenylylcarbamoyl)benzoic acid

Synonym

UNII-Q93BBN11CP

Solubility

DMSO 63 mg/mL Ethanol 5 mg/mL Water Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

K0271 MSDS PDF

Info Sheet

K0271 Info Sheet PDF

References

Liu C, Ma X, Li T, et al. Kartogenin, transforming growth factor-β1 and bone morphogenetic protein-7 coordinately enhance lubricin accumulation in bone-derived mesenchymal stem cells. Cell Biol Int. 2015 Apr 9. [Epub ahead of print]. PMID: 25857705.

Xu X, Shi D, Shen Y, et al. Full-thickness cartilage defects are repaired via a microfracture technique and intraarticular injection of the small-molecule compound kartogenin. Arthritis Res Ther. 2015 Feb 2;17:20. PMID: 25641548.

Zhang J, Wang JH. Kartogenin induces cartilage-like tissue formation in tendon-bone junction. Bone Res. 2014;2. pii: 14008. PMID: 25419468.

Decker RS, Koyama E, Enomoto-Iwamoto M, et al. Mouse limb skeletal growth and synovial joint development are coordinately enhanced by Kartogenin. Dev Biol. 2014 Nov 15;395(2):255-67. PMID: 25238962.

Custom Order

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