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Kavalactones Mixture

Kavalactones Mixture

Product ID K0282
Cas No.
Purity ≥98%
Product Unit SizeCostQuantityStock
1 ml $933.20 In stock
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  • Product Info
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

100 µg each of 13 kava compounds/ mL acetonitrile.

Kavalactones are found in Piper methysticum and exert a wide variety of activities in vitro and in vivo, including antinociceptive, anxiolytic, hypnotic, anticonvulsant, and anti-inflammatory effects. Kavalactones shorten sleep latency and decrease awake time in sleep-disturbed rats and effectively treat short-term anxiety in humans. In animals, these compounds also activate Nrf2, a transcription factor protective against aβ-induced neurotoxicity in Alzheimer’s disease and inhibit MPTP-induced loss of DA, tyrosine hydroxylase, and nigral neurons in models of Parkinson’s disease. Additionally, kavalactones modulate Na+, K+, and Ca2+ ion channel signaling as well as chemical and thermal pain nociception.

Product Info

Purity

≥98%

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

K0282 Info Sheet PDF

References

Kormann EC, Amaral Pde A, David M, et al. Kavain analogues as potential analgesic agents. Pharmacol Rep. 2012;64(6):1419-26. PMID: 23406752.

Tsutsui R, Shinomiya K, Takeda Y, et al. Hypnotic and sleep quality-enhancing properties of kavain in sleep-disturbed rats. J Pharmacol Sci. 2009 Nov;111(3):293-8. PMID: 19881224.

Wruck CJ, Götz ME, Herdegen T, et al. Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation. Mol Pharmacol. 2008 Jun;73(6):1785-95. PMID: 18334601.

Pittler MH, Ernst E. Kava extract for treating anxiety. Cochrane Database Syst Rev. 2003;(1):CD003383. PMID: 12535473.

Grunze H, Langosch J, Schirrmacher K, et al. Kava pyrones exert effects on neuronal transmission and transmembraneous cation currents similar to established mood stabilizers--a review. Prog Neuropsychopharmacol Biol Psychiatry. 2001 Nov;25(8):1555-70. PMID: 11642654.

Schmidt N, Ferger B. Neuroprotective effects of (+/-)-kavain in the MPTP mouse model of Parkinson's disease. Synapse. 2001 Apr;40(1):47-54. PMID: 11170221.

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