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Kynurenic acid is an endogenous antagonist of NMDA receptors, and exhibits neuroprotective effects. It is both an antiexcitotoxic and anticonvulsant. It and its analogues have been studied in a variety of neurological conditions and diseases, including Alzhheimer’s, schizophrenia, and age-related learning and memory impairment.
| Cas No. | 492-27-3 |
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| Purity | ≥99% |
| Formula | C10H7NO3 |
| Formula Wt. | 189.17 |
| Chemical Name | 4-Hydroxyquinoline-2-carboxylic acid |
| IUPAC Name | 4-oxo-1H-quinoline-2-carboxylic acid |
| Synonym | 4-Hydroxyquinoline-2-carboxylic acid, Kynurenate, Quinurenic acid, Transtorine, 4-oxo-1,4-dihydroquinoline-2-carboxylic acid, Kinurenic acid, Kynuronic acid, KYNA |
| Solubility | Soluble in water - 9 mg/mL. DMSO-5 mg/mL |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Elmslie K., Yoshikami D. Effects of kynurenate on root potentials evoked by synaptic activity and amino acids in the frog spinal cord. Brain Res. 330(2):265-72. PMID: 2985194.
Plitman E., Iwata Y., et al. Kynurenic Acid in Schizophrenia: A Systematic Review and Meta-analysis. Schizophr Bull. 43(4):764-77 (2017). PMID: 28187219.
Vohra M., Lemieux G., et al. Kynurenic acid accumulation underlies learning and memory impairment associated with aging. Genes Dev. 32(1);14-19 (2018). PMID: 29386332.