Lactacystin

Name: Lactacystin
SKU: L0107
Availability: InStock

Product ID L0107

Cas No. 133343-34-7

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Lactacystin is a proteasome inhibitor initially produced by Streptomyces that exhibits hepatoprotective, anti-metastatic, and anticancer chemotherapeutic activities. Lactacystin increases the Bax/Bcl-2 ratio and inhibits proliferation of cells and growth of tumors in models of glioma. Additionally, lactacystin inhibits growth and migration of smooth muscle cells. In animal models of intestinal ischemia/reperfusion-induced liver injury, lactacystin inhibits activation of NF-κB, suppresses infiltration of neutrophils, and decreases levels of ICAM-1.

Product Info

Cas No.	133343-34-7
Purity	≥98%
Formula	C₁₅H₂₄N₂O₇S
Formula Wt.	376.43
IUPAC Name	(2R)-2-acetamido-3-[(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidine-2-carbonyl]sulfanylpropanoic acid
Solubility	Soluble DMSO or water.
Appearance	White Solid

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	L0107 MSDS PDF
Info Sheet	L0107 Info Sheet PDF

References

Wang H, Zhang S, Zhong J, et al. The proteasome inhibitor lactacystin exerts its therapeutic effects on glioma via apoptosis: an in vitro and in vivo study. J Int Med Res. 2013 Feb;41(1):72-81. PMID: 23569132.

Barringhaus KG, Matsumura ME. The proteasome inhibitor lactacystin attenuates growth and migration of vascular smooth muscle cells and limits the response to arterial injury. Exp Clin Cardiol. 2007 Fall;12(3):119-24. PMID: 18650992.

Yao JH, Li YH, Wang ZZ, et al. Proteasome inhibitor lactacystin ablates liver injury induced by intestinal ischaemia-reperfusion. Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1102-8. PMID: 17880361.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Name
This field is for validation purposes and should be left unchanged.

Lactacystin

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Taxinin M

Tryprostatin A

Diphenhydramine Hydrochloride

Etidronate Disodium

LHRH Acetate Salt

Azithromycin Dihydrate

Lycopene

Apicidin

NG-52

Glucagon (19-29), human

Isorhamnetin

Isoniazid

Neosolaniol

Vitamin K3

Geranylgeraniol

Penitrem A

Tubeimoside I

SNS-032

Lacidipine

Raltitrexed

Footer