• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Lactacystin

Lactacystin

Product ID L0107
Cas No. 133343-34-7
Purity ≥98%
Product Unit SizeCostQuantityStock
100 µg $157.80 In stock
200 µg $277.90 In stock
500 µg $601.00 In stock
1 mg $1,126.90 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Lactacystin is a proteasome inhibitor initially produced by Streptomyces that exhibits hepatoprotective, anti-metastatic, and anticancer chemotherapeutic activities. Lactacystin increases the Bax/Bcl-2 ratio and inhibits proliferation of cells and growth of tumors in models of glioma. Additionally, lactacystin inhibits growth and migration of smooth muscle cells. In animal models of intestinal ischemia/reperfusion-induced liver injury, lactacystin inhibits activation of NF-κB, suppresses infiltration of neutrophils, and decreases levels of ICAM-1.

Product Info

Cas No.

133343-34-7

Purity

≥98%

Formula

C15H24N2O7S

Formula Wt.

376.43

IUPAC Name

(2R)-2-acetamido-3-[(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidine-2-carbonyl]sulfanylpropanoic acid

Solubility

Soluble DMSO or water.

Appearance

White Solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L0107 MSDS PDF

Info Sheet

L0107 Info Sheet PDF

References

Wang H, Zhang S, Zhong J, et al. The proteasome inhibitor lactacystin exerts its therapeutic effects on glioma via apoptosis: an in vitro and in vivo study. J Int Med Res. 2013 Feb;41(1):72-81. PMID: 23569132.

Barringhaus KG, Matsumura ME. The proteasome inhibitor lactacystin attenuates growth and migration of vascular smooth muscle cells and limits the response to arterial injury. Exp Clin Cardiol. 2007 Fall;12(3):119-24. PMID: 18650992.

Yao JH, Li YH, Wang ZZ, et al. Proteasome inhibitor lactacystin ablates liver injury induced by intestinal ischaemia-reperfusion. Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1102-8. PMID: 17880361.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T0140

    TAK-632

    RAF inhibitor.

    ≥99%
  • A985134

    AZD-9291

    EGFR inhibitor.

    ≥99%
  • P0268

    Parasin I

    Histone H2-derived antimicrobial peptide found ...

    ≥95%
  • T7132

    Triacetyl Resveratrol

    Resveratrol prodrug; potential SIRT1 activator....

    ≥99%
  • O9234

    Oxiconazole Nitrate

    Imidazole; 14-α demethylase inhibitor.

    ≥98%
  • C2951

    Chlortetracycline Hydrochloride

    Tetracycline; protein translation inhibitor, MM...

    ≥85%
  • E6814

    Erdosteine

    Thiol derivative, antioxidant.

    ≥98%
  • D1749

    Demecolcine

    Used to study embryonic cloning; microtubule po...

    ≥97%
  • T7135

    Triticonazole

    Triazole; 14-α demethylase inhibitor, potentia...

    ≥95%
  • P298576

    Phomopsin A

    Cyclic hexapeptide isolated from Phomopsis lept...

    ≥98%
  • R1777

    9-cis-Retinoic Acid

    Vitamin A derivative; RAR and RXR agonist.

    ≥99%
  • D3449

    Dimethoxycurcumin

    Curcumin derivative.

    ≥98%
  • V0274

    [Lys8]-Vasopressin

    Peptide, vasopressin analog; V1/2 agonist.

    ≥95%
  • S1604

    Secretin Acetate

    Endogenous peptide hormone, involved in feeding...

    ≥95%
  • A971334

    Azilsartan

    Sartan

    ≥98%
  • T0108

    10-Deacetyl-7-xylosyltaxol

    Taxane found in species of Taxus; potential mic...

    ≥98%
  • H0207

    Hepatitis B Virus Core Protein (128-140)

    B cell epitope found on hepatitis B viral core ...

    ≥95%
  • A4777

    Altiratinib

    c-MET, Tie-2, VEGFR inhibitor.

    ≥98%
  • L3550

    Limonin

    Furanolactone found in citrus fruits.

    ≥98%
  • E2542

    Met-Enkephalin Amide

    Endogenous opioid peptide; δOR and μOR agonis...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only