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Leptin (116-130), mouse

Leptin (116-130), mouse

Product ID L1661
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $245.30 Please Inquire
1 mg $417.10 Please Inquire
2.5 mg $735.90 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Leptin (116-130) is an active peptide fragment of leptin that increases levels of luteinizing hormone and prolactin. Leptin is an endogenous peptide that binds leptin receptors; it is involved in feeding behavior and energy homeostasis. Leptin exhibits anorexigenic, antihypertensive, and neuroprotective activities. Leptin induces secretion of α-melanocyte-stimulating hormone (α-MSH) and gonadotropin-releasing hormone (GnRH). Leptin (116-130) also decreases release of corticosterone and adrenocorticotropic hormone (ACTH) from the pituitary gland. In animal models, this peptide fragment of leptin inhibits human chorionic gonadotropin (hCG)-stimulated testosterone secretion as well as luteinizing hormone and follicle-stimulating hormone (FSH) secretion. In obese and diabetic mice, leptin (116-130) decreases blood glucose levels.

Product Info

Purity

≥95%

Formula

C64H108N18O25S

Formula Wt.

1561.73

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L1661 MSDS PDF

Info Sheet

L1661 Info Sheet PDF

References

Rozhavskaya-Arena M, Lee DW, Leinung MC, et al. Design of a synthetic leptin agonist: effects on energy balance, glucose homeostasis, and thermoregulation. Endocrinology. 2000 Jul;141(7):2501-7. PMID: 10875251.

Malendowicz LK, Tortorella C, Nowak KW, et al. Leptin prolonged administration inhibits the growth and glucocorticoid secretion of rat adrenal cortex. Endocr Res. 2000 May;26(2):141-52. PMID: 10921444.

Tena-Sempere M, Pinilla L, González LC, et al. In vitro pituitary and testicular effects of the leptin-related synthetic peptide leptin(116-130) amide involve actions both similar to and distinct from those of the native leptin molecule in the adult rat. Eur J Endocrinol. 2000 Apr;142(4):406-10. PMID: 10754484.

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