LKT Labs

Biochemicals for Life Science Research

Leu-Enkephalin

Leu-Enkephalin

Product ID E5240
Cas No. 58822-25-6
Purity ≥95%
Product Unit SizeCostQuantityStock
25 mg $114.00 In stock
50 mg $180.00 In stock
125 mg $343.00 In stock
Bulk Quote

Quicklinks

Description

Leu-enkephalin is an endogenous opioid peptide that acts as an agonist at μ-opioid receptors (μORs) and δ-opioid receptors (δORs). Met-enkephalin exhibits neuromodulatory, antinociceptive/analgesic, and gastrointestinal motility modulating activities. Like other endogenous opioids, leu-enkephalin modulates expression of opioid receptors and plays a role in reward/reinforcement signaling. Leu-enkephalin increases pain thresholds in vivo and inhibits gastrointestinal muscle contractility in other animal models, inhibiting motility and gastric emptying.

Product Info

Cas No.

58822-25-6
Purity

≥95%
Formula

C28H37N5O7
Formula Wt.

555.62
IUPAC Name

2-[[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
Synonym

1-5-b-Neoendorphin (human) (9CI)
Solubility

Soluble in water (1 mg/mL).
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

E5240 MSDS PDF
Info Sheet

E5240 Info Sheet PDF

References

Popov M, Abu Hammad I, Bachar T, et al. Delivery of analgesic peptides to the brain by nano-sized bolaamphiphilic vesicles made of monolayer membranes. Eur J Pharm Biopharm. 2013 Nov;85(3 Pt A):381-9. PMID: 23791683.

Crayton R, Soller W, Mattiasson A, et al. Exogenously administered opioids contract the female rat intrinsic urethral sphincter in vivo. Neurourol Urodyn. 2010 Jun;29(5):777-82. PMID: 19899147.

Holzer P. Opioid receptors in the gastrointestinal tract. Regul Pept. 2009 Jun 5;155(1-3):11-7. PMID: 19345246.

Del Borgo MP, Blanchfield JT, Toth I. Internalisation of the mu-opioid receptor by endomorphin-1 and leu-enkephalin is dependant on aromatic amino acid residues. Bioorg Med Chem. 2008 Apr 15;16(8):4341-6. PMID: 18329886.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G6802

    Granisetron Hydrochloride

    5-HT3 antagonist.

    ≥98%
  • K624760

    KPT-276

    CRM1/XPO1 inhibitor.

    ≥99%
  • C3578

    L-Citrulline

    Byproduct of L-arginine metabolism found in wat...

    ≥98%
  • V1668

    Vemurafenib

    B-Raf inhibitor.

    ≥98%
  • D3447

    Diltiazem Hydrochloride

    Benzothiazepine; L-type Ca2+ channel blocker, p...

    ≥98%
  • V3444

    Vilazodone

    5-HT1A partial agonist, SERT inhibitor.

    ≥98%
  • T7156

    Tropisetron Hydrochloride

    α7 nAChR partial agonist, 5-HT3 antagonist.

    ≥98%
  • M0009

    Macitentan

    ET-A/B antagonist.

    ≥99%
  • C0155

    10-Hydroxycamptothecin

    Camptothecin derivative; topoisomerase I inhibi...

    ≥98%
  • C5972

    Corynoline

    Alkaloid compound originally found in Corydalis...

    ≥98%
  • M5876

    Motesanib

    VEGFR1/2/3, PDGFR, c-Kit, RET inhibitor.

    ≥98%
  • N6076

    N(p-Tosyl)-GPR-pNA

    Thrombin substrate used to measure thrombin act...

    ≥95%
  • L9800

    LY-364947

    ALK5 (activin-like) inhibitor.

    ≥98%
  • C4502

    Clarithromycin

    Macrolide; protein translation inhibitor.

    ≥95%
  • V3326

    Virginiamycin S1

    Macrolide antibiotic; peptidyl transferase inhi...

    ≥99%
  • O5212

    Ondansetron Hydrochloride Dihydrate

    5-HT3 antagonist.

    ≥98%
  • D5747

    Dolasetron Mesylate Hydrate

    5-HT3 antagonist.

    ≥98%
  • X4424

    XL-765

    PI3K and mTOR inhibitor.

    ≥98%
  • L3561

    D,L-α-Lipoic Acid

    Endogenous organosulfur also found in meat and ...

    ≥99%
  • L0360

    Lapatinib Ditosylate Monohydrate

    EGFR inhibitor.

    ≥99%