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Levocetirizine Dihydrochloride

Levocetirizine Dihydrochloride

Product ID L1780
Cas No. 130018-87-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $79.10 In stock
5 g $164.00 In stock
25 g $631.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Levocetirizine ( (R)-Cetirizine dihydrochloride) is the L-isomer of cetirizine, a second-generation histamine H1 receptor antagonist. Levocetirizine exhibits anti-allergic, anti-inflammatory, and immunomodulatory activities. In animal models of allergic conjunctivitis, levocetirizine decreases levels of lipoxin A4, TNF-α, TGF-β, and antigen presenting cells (APCs) and increases levels of IL-10. Additionally, this compound increases levels of CD4+ CD25+ T cells and decreases levels of eosinophils, decreasing allergy symptoms in clinical settings.

Product Info

Cas No.

130018-87-0

Purity

≥98%

Formula

C21H25ClN2O3 • 2HCl

Formula Wt.

461.81

Chemical Name

Acetic acid, (2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1- piperazinyl)ethoxy)- hydrochloride

IUPAC Name

2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid;dihydrochloride

Synonym

(−)-Cetirizine, Xusal, Xyzal, (R)-Cetirizine dihydrochloride

Melting Point

215-220°C

Appearance

White to off-white crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

L1780 MSDS PDF

Info Sheet

L1780 Info Sheet PDF

References

García-Zepeda S, Estrada-Muñiz E, Elizondo G, et al. Levocetirizine inhibits migration of immune cells to lymph nodes and induces treg cells in a murine type I allergic conjunctivitis model. Open Ophthalmol J. 2012;6:129-36. PMID: 23284599.

Mahmoud F, Arifhodzic N, Haines D, et al. Levocetirizine modulates lymphocyte activation in patients with allergic rhinitis. J Pharmacol Sci. 2008 Oct;108(2):149-56. PMID: 18946193.

Custom Order

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