• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Loperamide Hydrochloride

Loperamide Hydrochloride

Product ID L5660
Cas No. 34552-83-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $92.00 In stock
25 g $377.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Loperamide is a μ-opioid receptor (μOR) agonist that exhibits gastrointestinal motility modulating, anorexigenic, analgesic, and antinociceptive activities; it also potentially inhibits HCN channels. Loperamide is clinically used as an anti-diarrheal drug as it increases gastric emptying and decreases bowel water content. Loperamide also alters pain thresholds in animal models as measured by the Hargreaves paw withdrawal apparatus. Additionally, loperamide decreases foraging behavior and body weight in vivo. Loperamide also acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.

34552-83-5

Purity

≥98%

Formula

C29H33ClN2O2 • HCl

Formula Wt.

513.51

Chemical Name

4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α- diphenyl-1-piperidinbutanamide hydrochloride

IUPAC Name

4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2, 2-diphenylbutanamide;hydrochloride

Synonym

Imodium, Tebloc, Dissenten, Lopemin

Melting Point

222-223°C

Solubility

Soluble in methanol or chloroform.

Appearance

White or Almost White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

L5660 MSDS PDF

Info Sheet

L5660 Info Sheet PDF

References

Kumar R. Loperamide: from antidiarrheal to analgesic. J Opioid Manag. 2013 Jul-Aug;9(4):301-2. PMID: 24353024.

Kumar R, Reeta KH, Ray SB. Antinociceptive effect of intrathecal loperamide: role of mu-opioid receptor and calcium channels. Eur J Pharmacol. 2012 Dec 5;696(1-3):77-82. PMID: 23022331.

Placidi E, Marciani L, Hoad CL, et al. The effects of loperamide, or loperamide plus simethicone, on the distribution of gut water as assessed by MRI in a mannitol model of secretory diarrhoea. Aliment Pharmacol Ther. 2012 Jul;36(1):64-73. PMID: 22582872.

Chumakova YA, Bashkatova VG, Sudakov SK. Changes in feeding behavior after peripheral loperamide administration in rats. Bull Exp Biol Med. 2011 Feb;150(4):398-400. PMID: 22268026.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G062680

    GBR-12909 Dihydrochloride

    Dopamine reuptake inhibitor (DRI).

    ≥98%
  • C0366

    Carvedilol Phosphate Hemihydrate

    FIASMA; α1- and β1/2-adrenergic antagonist.

    ≥98%
  • T7033

    Trifluoperazine Dihydrochloride

    Phenothiazine; D1/2 and α1-adrenergic antagoni...

    ≥98%
  • M002698

    M2698

    Dual inhibitor of p70S6K and Akt.

    ≥99%
  • T0119

    Taxol Side Chain β-lactam

    Taxol synthesis intermediate.

    ≥98%
  • A1369

    Adrenomedullin (13-52), human

    Endogenous peptide hormone, involved in cell gr...

    ≥95%
  • C0168

    Canthaxanthin

    Carotenoid terpene pigment found in various pla...

    ≥9% (product contains stabilizers)
  • D0353

    Danofloxacin Mesylate

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • C9880

    Cytochalasin C

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%, TLC
  • A6132

    Apicidin

    Cyclic tetrapeptide; HDAC inhibitor.

    ≥98%
  • A9603

    5-Aza-2′-deoxycytidine

    Nucleoside (deoxycytidine) analog; DNMT inhibit...

    ≥98%
  • P004080

    PAC-1

    Zinc chelator

    ≥98%
  • Z161023

    β-Zearalanol

    Mycotoxin that has structural similarity to est...

    ≥98%
  • C179603

    CEP-37440 Hydrochloride

    Inhibitor of FAK and ALK.

    ≥99%
  • L8010

    D-Luciferin Potassium

    Heterocyclic light-emitting compound, natural l...

    ≥98%
  • P9671

    Pyrazinamide

    Nicotinamide analog prodrug; fatty acid synthet...

    ≥98%
  • D5746

    Dolasetron

    5-HT3 antagonist.

    ≥98%
  • N0114

    Nadifloxacin

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • P0092

    Paclitaxel, from Taxus yunnanensis

    Diterpene found in Taxus yunnanensis; microtubu...

    ≥98%
  • B165122

    Bedaquiline

    Bactericidal

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only