Description
Losartan Carboxylic acid (EXP3174) is an active metabolite of Losartan. It was found to be more potent than losartan in blocking the angiotensin II-induced responses in vascular smooth muscle cells.
Losartan Carboxylic acid
Product ID L283720
Cas No. 124750-92-1
Purity ≥ 99%
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Product Info
| Cas No. | 124750-92-1 |
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| Purity | ≥ 99% |
| Formula | C22H21ClN6O2 |
| Formula Wt. | 436.9 |
| Chemical Name | 2-Butyl-4-chloro-1-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid |
| IUPAC Name | 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid |
| Synonym | EXP3174, EXP-3174 |
| Melting Point | 153-158°C |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Gromotowicz-Poplawska A, Nazarko-Sadowska J, Chabielska E. Losartan metabolite EXP3174 reduces the weight of formed thrombus in 2K1C hypertensive rats. J Physiol Pharmacol. 2019 Jun;70(3). doi: 10.26402/jpp.2019.3.11. Epub 2019 Sep 27. PMID: 31566190.
Sachinidis A, Ko Y, Weisser P, et.al. EXP3174, a metabolite of losartan (MK 954, DuP 753) is more potent than losartan in blocking the angiotensin II-induced responses in vascular smooth muscle cells. J Hypertens. 1993 Feb;11(2):155-62. doi: 10.1097/00004872-199302000-00007. PMID: 8385175.
Wong PC, Price WA Jr, Chiu AT, et al. Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent. J Pharmacol Exp Ther. 1990 Oct;255(1):211-7. PMID: 2213556.