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Losartan Carboxylic acid

Losartan Carboxylic acid

Product ID L283720
Cas No. 124750-92-1
Purity ≥ 99%
Product Unit SizeCostQuantityStock
5 mg $98.00 In stock
5 mg $106.80 In stock
5 mg $112.10 In stock
5 mg $112.10 In stock
5 mg $117.70 In stock
25 mg $330.50 In stock
50 mg $598.40 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Losartan Carboxylic acid (EXP3174) is an active metabolite of Losartan. It was found to be more potent than losartan in blocking the angiotensin II-induced responses in vascular smooth muscle cells.

Product Info

Cas No.

124750-92-1

Purity

≥ 99%

Formula

C22H21ClN6O2

Formula Wt.

436.9

Chemical Name

2-Butyl-4-chloro-1-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid

IUPAC Name

2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid

Synonym

EXP3174, EXP-3174

Melting Point

153-158°C

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L283720 MSDS PDF

Info Sheet

L283720 Info Sheet PDF

References

Gromotowicz-Poplawska A, Nazarko-Sadowska J, Chabielska E. Losartan metabolite EXP3174 reduces the weight of formed thrombus in 2K1C hypertensive rats. J Physiol Pharmacol. 2019 Jun;70(3). doi: 10.26402/jpp.2019.3.11. Epub 2019 Sep 27. PMID: 31566190.

Sachinidis A, Ko Y, Weisser P, et.al. EXP3174, a metabolite of losartan (MK 954, DuP 753) is more potent than losartan in blocking the angiotensin II-induced responses in vascular smooth muscle cells. J Hypertens. 1993 Feb;11(2):155-62. doi: 10.1097/00004872-199302000-00007. PMID: 8385175.

Wong PC, Price WA Jr, Chiu AT, et al. Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent. J Pharmacol Exp Ther. 1990 Oct;255(1):211-7. PMID: 2213556.

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