Description
LY-3200882 is an inhibitor of TGFβR1. The TGF-β pathway is frequently deregulated in tumors, and plays an important role in the regulation of cell growth, differentiation, and apopsosis. Preliminary safety and efficacy studies suggest that LY-3200882 is for patients with certain advanced or metastatic cancers, for example it inhibits tumor growth in preclinical models of triple negative breast cancer.