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LY-364947

LY-364947

Product ID L9800
Cas No. 396129-53-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $75.10 In stock
5 mg $143.70 In stock
25 mg $506.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

LY364947 is an inhibitor of activin receptor-like kinase 5 (ALK5), a type of TGF-β1 receptor. LY364947 displays anticancer and anti-fibrotic activities. LY364947 improves the radiosensitivity of non-small cell lung cancer (NSCLC) cells. In animal models of liver damage, this compound enhances liver regeneration, cell proliferation, and liver function.

Product Info

Cas No.

396129-53-6

Purity

≥98%

Formula

C17H12N4

Formula Wt.

272.31

IUPAC Name

4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]quinoline

Synonym

LY364947

Solubility

DMSO 1 mg/mL (3.67 mM) Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L9800 MSDS PDF

Info Sheet

L9800 Info Sheet PDF

References

Du S, Bouquet S, Lo CH, et al. Attenuation of the DNA damage response by transforming growth factor-beta inhibitors enhances radiation sensitivity of non-small-cell lung cancer cells in vitro and in vivo. Int J Radiat Oncol Biol Phys. 2015 Jan 1;91(1):91-9. PMID: 25835621.

Karkampouna S, Goumans MJ, Ten Dijke P, et al. Inhibition of TGFβ type I receptor activity facilitates liver regeneration upon acute CCl4 intoxication in mice. Arch Toxicol. 2015 Jan 8. [Epub ahead of print]. PMID: 25566828.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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