• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
LY-364947

LY-364947

Product ID L9800
Cas No. 396129-53-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $75.10 In stock
5 mg $143.70 In stock
25 mg $506.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

LY364947 is an inhibitor of activin receptor-like kinase 5 (ALK5), a type of TGF-β1 receptor. LY364947 displays anticancer and anti-fibrotic activities. LY364947 improves the radiosensitivity of non-small cell lung cancer (NSCLC) cells. In animal models of liver damage, this compound enhances liver regeneration, cell proliferation, and liver function.

Product Info

Cas No.

396129-53-6

Purity

≥98%

Formula

C17H12N4

Formula Wt.

272.31

IUPAC Name

4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]quinoline

Synonym

LY364947

Solubility

DMSO 1 mg/mL (3.67 mM) Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L9800 MSDS PDF

Info Sheet

L9800 Info Sheet PDF

References

Du S, Bouquet S, Lo CH, et al. Attenuation of the DNA damage response by transforming growth factor-beta inhibitors enhances radiation sensitivity of non-small-cell lung cancer cells in vitro and in vivo. Int J Radiat Oncol Biol Phys. 2015 Jan 1;91(1):91-9. PMID: 25835621.

Karkampouna S, Goumans MJ, Ten Dijke P, et al. Inhibition of TGFβ type I receptor activity facilitates liver regeneration upon acute CCl4 intoxication in mice. Arch Toxicol. 2015 Jan 8. [Epub ahead of print]. PMID: 25566828.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A488246

    AMG-232

    MDM2-p53 inhibitor

    ≥99%
  • M3379

    Mitoxantrone Dihydrochloride

    Anthracenedione, DNA intercalator; Pim-1 inhibi...

    ≥98%
  • G2969

    Growth Hormone Releasing Hexapeptide

    Synthetic peptide hormone, met-enkephalin analo...

    ≥95%
  • D0004

    Dabrafenib

    B-Raf and c-Raf inhibitor.

    ≥98%
  • W9602

    WY-14643

    A peroxisome proliferator-activated receptor ag...

    ≥98%
  • N1976

    Netilmicin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • I7359

    1-Isothiocyanato-8-(methylsulfenyl)-octane

    ITC, erucin analog.

    ≥98%
  • N5986

    Novobiocin Sodium

    Aminocoumarin; bacterial DNA gyrase inhibitor.<...

    ≥98%
  • A9662

    AZ-628

    B-Raf and c-Raf inhibitor.

    ≥96%
  • C5654

    Concanavalin A

    Lectin found in Canavelia, plant mitogen that b...

  • T1733

    Teicoplanin

    Glycopeptide, vancomycin analog; peptidoglycan ...

    ≥900 ug/mg, bio assay
  • N3378

    S-Nitrosoglutathione

    NO donor.

    ≥95%
  • C4759

    Clozapine N-oxide

    Inert clozapine analog, activates specialized G...

    ≥98%
  • T0106

    Xylosyltaxol

    Taxane found in species of Taxus; potential mic...

    ≥98%
  • O2146

    R-(+)-Ofloxacin

    Fluoroquinolone, optically active isomer of ofl...

    ≥98%
  • B030962

    BAY-1251152

    Inhibitor of PTEFb/CDK9.

    ≥98%
  • A4802

    Amantadine Hydrochloride

    Viral M2 proton channel blocker, MAO-A, NET, NM...

    ≥98%
  • D178589

    1-Deoxynojirimycin

    Anti-diabetic alkaloid

    ≥98%
  • L1881

    Leuprolide Acetate

    GnRH analog; GnRH1 agonist.

    ≥95%
  • Z1216

    Z-DEVD-AMC

    Caspase substrate.
    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only