• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
LY-364947

LY-364947

Product ID L9800
Cas No. 396129-53-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $75.10 In stock
5 mg $143.70 In stock
25 mg $506.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

LY364947 is an inhibitor of activin receptor-like kinase 5 (ALK5), a type of TGF-β1 receptor. LY364947 displays anticancer and anti-fibrotic activities. LY364947 improves the radiosensitivity of non-small cell lung cancer (NSCLC) cells. In animal models of liver damage, this compound enhances liver regeneration, cell proliferation, and liver function.

Product Info

Cas No.

396129-53-6

Purity

≥98%

Formula

C17H12N4

Formula Wt.

272.31

IUPAC Name

4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]quinoline

Synonym

LY364947

Solubility

DMSO 1 mg/mL (3.67 mM) Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L9800 MSDS PDF

Info Sheet

L9800 Info Sheet PDF

References

Du S, Bouquet S, Lo CH, et al. Attenuation of the DNA damage response by transforming growth factor-beta inhibitors enhances radiation sensitivity of non-small-cell lung cancer cells in vitro and in vivo. Int J Radiat Oncol Biol Phys. 2015 Jan 1;91(1):91-9. PMID: 25835621.

Karkampouna S, Goumans MJ, Ten Dijke P, et al. Inhibition of TGFβ type I receptor activity facilitates liver regeneration upon acute CCl4 intoxication in mice. Arch Toxicol. 2015 Jan 8. [Epub ahead of print]. PMID: 25566828.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T1678

    D,L-Tetrahydropalmatine

    Alkaloid found in Corydalis and Stephania; D1/2...

    ≥98%
  • J5237

    JNJ-26854165

    MDM2 inhibitor.

    ≥98%
  • P200091

    PF-07104091

    CDK2 inhibitor

    ≥98%
  • C1878

    Cetrimide

    Mixture of quaternary ammonium salts, cationic ...

    ≥98%
  • R2917

    Rhein

    Diacerein metabolite, anthraquinone found in Rh...

    ≥88%
  • B030967

    BAY-1895344

    ATR inhibitor.

    ≥99%
  • B3211

    (+)-Bicuculline

    NMDA potentiator, GABA-A antagonist.

    ≥98%
  • O6805

    Orbifloxacin

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥99%
  • A5378

    Antimycin A

    Oxidative phosphorylation inhibitor.

  • A5135

    Aminophylline Dihydrate

    Xanthine derivative; adenosine antagonist, PDE ...

    ≥98%
  • V1868

    Veratramine

    Steroidal alkaloid found in Veratrum and Fritil...

    ≥98%
  • X1854

    p-Xyleneselenocyanate

    Synthetic derivative of selenocyanate.

    ≥99%
  • S8044

    R,S-Sulforaphane, High Purity

    Phase II enzyme inducer; Nrf2 activator; antiox...

    ≥99%
  • C0375

    Ac-DEVD-pNA

    Caspase 3 substrate.

    ≥95%
  • S1872

    Sesamin

    Lignin found in Sesamin indicum;

    ≥98%
  • A9714

    AZD-1152-HQPA

    AurKA/B inhibitor.

    ≥98%
  • T2935

    Thiamphenicol

    Chloramphenicol derivative; protein translation...

    ≥98%
  • G3351

    Ginkgolic Acid (17:1)

    Mixture of alkylphenols found in Ginkgo; HIV pr...

    ≥98%
  • H0142

    Haloperidol

    Butyrophenone; σ2 agonist, α1-adrenergic, D2,...

    ≥95%
  • C8069

    Curcumin

    Diarylheptanoid found in Zingiberaceae.

    ≥97% curcuminoid content

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only