Manumycin A

Name: Manumycin A
SKU: M017545
Availability: InStock

Product ID M017545

Cas No. 52665-74-4

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Manumycin A is a natural antibiotic found in Streptomyces parvulus that is known to inhibit the enzyme farnesyl transferase. Manumycin A has been found to induce apoptosis, inhibit the PI3K-AKT pathway, and decrease expression of caspase-9 and PARP in human colorectal cancer cells. The result of manumycin A on human oral squamous cancer cells was inhibition of cell viability, induction of apoptosis, regulation of transcription factor Sp1, and control of mitochondrial membrane permeability. In a mouse model of muscular dystrophy, treatment with manumycin A corrected aberrant splicing of Clcn1 gene.

Product Info

Cas No.	52665-74-4
Purity	≥98%
Formula	C₃₁H₃₈N₂O₇
Formula Wt.	550.65
Chemical Name	(2E,4E,6R)-N-[(5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-7-oxohepta-1,3,5-trienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyldeca-2,4-dienamide
IUPAC Name	(2E,4E,6R)-N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-7-oxohepta-1,3,5-trienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyldeca-2,4-dienamide
Synonym	Manumycin-A; 2,4-Decadienamide, N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyl-, (2E,4E,6R)- (9CI); (2E,4E,6R)-N-[(1S,5S,6R)-5-Hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrien-1-yl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyl-2,4-decadienamide
Solubility	Soluble in methanol or DMSO; Insoluble in water.
Appearance	Yelow powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	M017545 MSDS PDF
Info Sheet	M017545 Info Sheet PDF

References

Zhang J, Jiang H, Xie L, et al. Antitumor effect of manumycin A on colorectal cancer cells by increasing the reactive oxygen species production and blocking PI3K-AKT pathway. Onco Targets Ther. 2016 May 24;9:2885-2895. PMID: 27307747.

Cho JJ, Chae JI, Kim KH, et al. Manumycin A from a new Streptomyces strain induces endoplasmic reticulum stress-mediated cell death through specificity protein 1 signaling in human oral squamous cell carcinoma. Int J Oncol. 2015 Nov;47(5):1954-1962. PMID: 26352011.

Li JG, She MR, Lu CY, et al. Manumycin induces apoptosis in prostate cancer cells. Onco Targets Ther. 2014 May 22;7:771-777. PMID: 24899815.

Oana K, Oma Y, Suo S, et al. Manumycin A corrects aberrant splicing of Clcn1 in myotonic dystrophy type 1 (DM1) mice. Sci Rep. 2013;3:2142. PMID: 23828222.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

Manumycin A

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Docosahexaenoic Acid (all cis-4,7,10,13,16,19)

D,L-1’-Acetoxychavicol acetate

Geranylgeraniol

Idarubicin Hydrochloride

Tubacin

Epirubicin Hydrochloride

Desoxypipradrol

S-(−)-Carbidopa Monohydrate

Aflatoxin B1

Norfloxacin Hydrochloride

K252b

Clenbuterol Hydrochloride

Cycloheximide

Apararenone

Sarafloxacin Hydrochloride

Hypothemycin

Zafirlukast

Altiratinib

D,L-α-Lipoic Acid

Kanamycin B

Footer