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Matrine

Matrine

Product ID M0278
Cas No. 519-02-8
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $97.70 In stock
100 mg $157.80 In stock
500 mg $450.80 In stock
1 g $676.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Matrine is an alkaloid found in Sophora that exhibits anticancer chemotherapeutic, antinociceptive, anti-inflammatory, neuroprotective, anti-fibrotic, and antiepileptic/anticonvulsant activities. Matrine increases levels of Bax and decreases levels of Bcl-2 and VEGF-A in non-small cell lung cancer (NSCLC) and hepatoma cells, inducing apoptosis and inhibiting cell growth. Matrine also inhibits growth of hepatocellular carcinoma tumors in animal models. In animal models of chemical and thermal pain (writhing and tail flick tests), matrine decreases pain response in a κ-opioid receptor (κOR)- and μ-opioid receptor (μOR)-dependent manner. Additionally, matrine downregulates levels of glutamate and upregulates levels of GABA, regulating glutamate signaling and inhibiting inflammation and demyelination in animal models of experimental autoimmune encephalitis (EAE) and decreasing seizures in separate animal models. Matrine also inhibits JAK/STAT signaling, decreasing pulmonary fibrosis in vivo.

Product Info

Cas No.

519-02-8

Purity

≥98%

Formula

C15H24N2O

Formula Wt.

248.37

Chemical Name

Matridin-15-one

IUPAC Name

(1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one

Synonym

Sophocarpidine

Melting Point

87°C

Solubility

Soluble in water, benzene, chloroform, ether, and carbon disulfide.

Appearance

White or Off-white Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

M0278 MSDS PDF

Info Sheet

M0278 Info Sheet PDF

References

Kan QC, Zhang S, Xu YM, et al. Matrine regulates glutamate-related excitotoxic factors in experimental autoimmune encephalomyelitis. Neurosci Lett. 2014 Feb 7;560:92-7. PMID: 24368216.

Xiang J, Jiang Y. Antiepileptic potential of matrine via regulation the levels of gamma-aminobutyric acid and glutamic acid in the brain. Int J Mol Sci. 2013 Dec 5;14(12):23751-61. PMID: 24317434.

Ma X, Chen R, Liu X, et al. Effects of matrine on JAK-STAT signaling transduction pathways in bleomycin-induced pulmonary fibrosis. Afr J Tradit Complement Altern Med. 2013 Apr 12;10(3):442-8. PMID: 24146473.

Zhang Y, Zhang H, Yu P, et al. Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration. Cytotechnology. 2009 Apr;59(3):191-200. PMID: 19649719.

Ma L, Wen S, Zhan Y, et al. Anticancer effects of the Chinese medicine matrine on murine hepatocellular carcinoma cells. Planta Med. 2008 Feb;74(3):245-51. PMID: 18283616.

Xiao P, Kubo H, Ohsawa M, et al. kappa-Opioid receptor-mediated antinociceptive effects of stereoisomers and derivatives of (+)-matrine in mice. Planta Med. 1999 Apr;65(3):230-3. PMID: 10232067.

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