MDL 29951

Name: MDL 29951
SKU: M1444
Availability: InStock

Product ID M1444

Cas No. 130798-51-5

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

MDL 29951 acts as an agonist at GPR17, inhibiting maturation of primary oligodendrocytes and potentially promoting myelin repair in models of multiple sclerosis. MDL 29951 also inhibits NMDA receptors at the glycine site as well as fructose 1,6-bisphosphatase. This compound displays neuromodulatory, anticonvulsant, and antinociceptive activities. In vivo, MDL 29951 inhibits formalin-induced licking. In animal models of seizures, this compound increases thresholds for the development of chemically-induced seizures.

Product Info

Cas No.	130798-51-5
Purity	≥98%
Formula	C₁₂H₉Cl₂NO₄
Formula Wt.	302.11
IUPAC Name	3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid
Synonym	MDL29951
Solubility	10 mM in DMSO
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	M1444 MSDS PDF
Info Sheet	M1444 Info Sheet PDF

References

Hennen S, Wang H, Peters L, et al. Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist. Sci Signal. 2013 Oct 22;6(298):ra93. PMID: 24150254.

Wright SW, Carlo AA, Danley DE, et al. 3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8. PMID: 12781194.

Millan MJ, Seguin L. Chemically-diverse ligands at the glycine B site coupled to N-methyl-D-aspartate (NMDA) receptors selectively block the late phase of formalin-induced pain in mice. Neurosci Lett. 1994 Aug 29;178(1):139-43. PMID: 7816323.

Baron BM, Harrison BL, McDonald IA, et al. Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site. J Pharmacol Exp Ther. 1992 Sep;262(3):947-56. PMID: 1388205.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

MDL 29951

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

LDK378

Dacomitinib Anhydrous

Pemetrexed Disodium

Dacomitinib Monohydrate

2-Hydroxyestradiol

Latrunculin B

Phleomycin

Gliotoxin

1-Isothiocyanato-7-(methylsulfonyl)-heptane

Lactacystin

SN-011

Telbivudine

Glucagon-like Peptide I Amide (7-36), human

Risedronate Sodium Hydrate

Genistin

Thiabendazole

Vitamin D2

Celastrol

Calcitonin Gene Related Peptide (8-37), human

(−)-Gallocatechin

Footer