LKT Labs

Biochemicals for Life Science Research

MDL 29951

MDL 29951

Product ID M1444
Cas No. 130798-51-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $76.00 In stock
5 mg $245.00 In stock
10 mg $380.00 In stock
Bulk Quote

Quicklinks

Description

MDL 29951 acts as an agonist at GPR17, inhibiting maturation of primary oligodendrocytes and potentially promoting myelin repair in models of multiple sclerosis. MDL 29951 also inhibits NMDA receptors at the glycine site as well as fructose 1,6-bisphosphatase. This compound displays neuromodulatory, anticonvulsant, and antinociceptive activities. In vivo, MDL 29951 inhibits formalin-induced licking. In animal models of seizures, this compound increases thresholds for the development of chemically-induced seizures.

Product Info

Cas No.

130798-51-5
Purity

≥98%
Formula

C12H9Cl2NO4
Formula Wt.

302.11
IUPAC Name

3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid
Synonym

MDL29951
Solubility

10 mM in DMSO
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

M1444 MSDS PDF
Info Sheet

M1444 Info Sheet PDF

References

Hennen S, Wang H, Peters L, et al. Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist. Sci Signal. 2013 Oct 22;6(298):ra93. PMID: 24150254.

Wright SW, Carlo AA, Danley DE, et al. 3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8. PMID: 12781194.

Millan MJ, Seguin L. Chemically-diverse ligands at the glycine B site coupled to N-methyl-D-aspartate (NMDA) receptors selectively block the late phase of formalin-induced pain in mice. Neurosci Lett. 1994 Aug 29;178(1):139-43. PMID: 7816323.

Baron BM, Harrison BL, McDonald IA, et al. Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site. J Pharmacol Exp Ther. 1992 Sep;262(3):947-56. PMID: 1388205.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A7203

    AS-703026

    MEK1/2 inhibitor.

    ≥98%
  • J3204

    E-JIB-04

    Jumonji histone demethylase inhibitor.

    ≥98%
  • I0516

    I-BET151

    BRD2/3/4 inhibitor.

    ≥98%
  • O9334

    Oxibendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • C2956

    Cholecalciferol

    Endogenous vitamin D prodrug.

    ≥98%
  • D5753

    Donepezil Hydrochloride

    GSK3 and AChE inhibitor, potential σ1 agonist....

    ≥98%
  • C9773

    L-Cystine

    Endogenous amino acid, forms disulfide bridges ...

    ≥98%
  • F4502

    Flavokawain A

    Chalcone kavalactone found in Piper methysticum...

    ≥98%
  • G0096

    GAY

    Tripeptide, used to tag proteins.

    ≥95%
  • C9200

    CX-6258

    Pim kinase inhibitor.

    ≥98%
  • S8047

    R,S-Sulforaphane, Research Grade

    Synthetic ITC.

    ≥97%
  • O5212

    Ondansetron Hydrochloride Dihydrate

    5-HT3 antagonist.

    ≥98%
  • C4457

    Clomipramine Hydrochloride

    FIASMA, mAChR, 5-HT2/3/6/7, α1/2-adrenergic an...

    ≥98%
  • U6801

    Urapidil

    5-HT1A agonist, α1-adrenergic antagonist.

    ≥98%
  • F5868

    Formoterol Fumarate Dihydrate

    β2-adrenergic agonist.

    ≥98%
  • B6935

    Brivudine

    Nucleoside (thymidine) analog; DNA chain termin...

    ≥98%
  • C9660

    Cypermethrin

    Synthetic type II pyrethroid insecticide; prote...

    ≥95%
  • M174446

    Meleagrin

    FabI inhibitor

    ≥99%
  • D1777

    Desmopressin Acetate

    Synthetic peptide, vasopressin derivative; V2 a...

    ≥95%
  • C0263

    L-Carnitine Hydrochloride

    Endogenous quaternary ammonium, required for fa...

    ≥98%