LKT Labs

Biochemicals for Life Science Research

MDL 29951

MDL 29951

Product ID M1444
Cas No. 130798-51-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $76.00 In stock
5 mg $245.00 In stock
10 mg $380.00 In stock
Bulk Quote

Quicklinks

Description

MDL 29951 acts as an agonist at GPR17, inhibiting maturation of primary oligodendrocytes and potentially promoting myelin repair in models of multiple sclerosis. MDL 29951 also inhibits NMDA receptors at the glycine site as well as fructose 1,6-bisphosphatase. This compound displays neuromodulatory, anticonvulsant, and antinociceptive activities. In vivo, MDL 29951 inhibits formalin-induced licking. In animal models of seizures, this compound increases thresholds for the development of chemically-induced seizures.

Product Info

Cas No.

130798-51-5
Purity

≥98%
Formula

C12H9Cl2NO4
Formula Wt.

302.11
IUPAC Name

3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid
Synonym

MDL29951
Solubility

10 mM in DMSO
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

M1444 MSDS PDF
Info Sheet

M1444 Info Sheet PDF

References

Hennen S, Wang H, Peters L, et al. Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist. Sci Signal. 2013 Oct 22;6(298):ra93. PMID: 24150254.

Wright SW, Carlo AA, Danley DE, et al. 3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8. PMID: 12781194.

Millan MJ, Seguin L. Chemically-diverse ligands at the glycine B site coupled to N-methyl-D-aspartate (NMDA) receptors selectively block the late phase of formalin-induced pain in mice. Neurosci Lett. 1994 Aug 29;178(1):139-43. PMID: 7816323.

Baron BM, Harrison BL, McDonald IA, et al. Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site. J Pharmacol Exp Ther. 1992 Sep;262(3):947-56. PMID: 1388205.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • K7600

    KT5720

    PKA and PDK1 inhibitor, HCN channel blocker, po...

    ≥98%
  • A5284

    [Val5]-Angiotensin II, human

    Peptide, derivative of AT II, involved in vasoc...

    ≥95%
  • I0801

    IC261

    Casein kinase 1 inhibitor.

    ≥98%
  • B3278

    Biotin

    Water-soluble coenzyme, vitamin (B7) found in v...

    ≥98%
  • D1627

    Dehydrocostus Lactone

    Sesquiterpene lactone found in Saussurea.

    ≥98%
  • D1769

    Dermorphin

    Opioid peptide; μOR agonist.

    ≥96%
  • B465806

    BLU-667

    RET inhibitor.

    ≥98%
  • R3475

    Risperidone

    Benzisoxazole; 5-HT7 and NMDA agonist, D-amino ...

    ≥98%
  • L5658

    Lonidamine

    Hexokinase inhibitor, aerobic glycolysis inhibi...

    ≥98%
  • O8500

    Ovalbumin Fragment (257-264)

    OVA antigen.

    ≥98%
  • O6845

    Orlistat

    Fatty acid synthase inhibitor.

    ≥98%
  • G3358

    Ginkgolide ABC

    Mixture of Ginkgolides A, B and C, found in Gin...

    ≥98%
  • G4434

    Gliotoxin

    Toxin produced by Aspergillus.

    ≥98%
  • C3208

    Ciclopirox Olamine

    Hydroxypyridone, metal ion chelator; mTOR inhib...

    ≥98%
  • M1335

    Mdivi-1

    Quinazolinone; mitochondrial division inhibitor...

    ≥98%
  • G823720

    Gusacitinib

    SYK/JAK inhibitor

    ≥98%
  • M1669

    6-Mercaptopurine Monohydrate

    Thiopurine antimetabolite; PRPP amidotransferas...

    ≥98%
  • B8676

    BVT-2733

    11β-HSD1 inhibitor.

    ≥98%
  • E5211

    Endomorphin-2

    Endogenous opioid peptide; μOR agonist.

    ≥95%
  • K5606

    Kobe 2602

    Ras inhibitor.

    ≥98%