• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Mecamylamine Hydrochloride

Mecamylamine Hydrochloride

Product ID M1708
Cas No. 826-39-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $77.70 In stock
25 mg $281.60 In stock
100 mg $901.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Mecamylamine is a reversible, non-competitive, non-selective inhibitor of nicotinic acetylcholine receptors (nAChRs); it decreases channel open time and burst duration. This compound exhibits antihypertensive, antidepressant, and anxiolytic activities. Mecamylamine crosses the blood-brain barrier and acts both centrally and peripherally, resulting in high incidence of peripheral side effects. Mecamylamine was previously clinically used to decrease blood pressure, but also reduces mood instability and depression in subjects with Tourette’s syndrome and shows potential benefit as a smoking cessation therapy. In animals, mecamylamine improves activity in the forced swim test, social interaction tests, and light/dark paradigms.

Product Info

Cas No.

826-39-1

Purity

≥98%

Formula

C11H21N • HCl

Formula Wt.

203.75

IUPAC Name

N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine;hydrochloride

Synonym

inversine, 2-(methylamino)isocamphane hydrochloride, N,2,3,3-tetramethyl-2-norbornanamine, N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride

Melting Point

245.5-246.5°C (dec)

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M1708 MSDS PDF

Info Sheet

M1708 Info Sheet PDF

References

Peng C, Kimbrell MR, Tian C, et al. Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents. Mol Pharmacol. 2013 Sep;84(3):459-75. PMID: 23839567.

Sanberg PR, Vindrola-Padros C, Shytle RD. Translating laboratory discovery to the clinic: from nicotine and mecamylamine to Tourette's, depression, and beyond. Physiol Behav. 2012 Dec 5;107(5):801-8. PMID: 22776623.

LeSage MG, Shelley D, Pravetoni M, et al. Enhanced attenuation of nicotine discrimination in rats by combining nicotine-specific antibodies with a nicotinic receptor antagonist. Pharmacol Biochem Behav. 2012 Jul;102(1):157-62. PMID: 22503967.

Bacher I, Wu B, Shytle DR, et al. Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. Expert Opin Pharmacother. 2009 Nov;10(16):2709-21. PMID: 19874251.

Lippiello PM, Beaver JS, Gatto GJ, et al. TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity. CNS Neurosci Ther. 2008 Winter;14(4):266-77. PMID: 19040552.

Shytle RD, Penny E, Silver AA, et al. Mecamylamine (Inversine): an old antihypertensive with new research directions. J Hum Hypertens. 2002 Jul;16(7):453-7. PMID: 12080428.

Hayashi E, Yamada S, Mori M. Comparative studies on anti-nicotinic action of hexamethonium, mecamylamine and adenosine in the guinea pig isolated ileum. Jpn J Pharmacol. 1977 Oct;27(5):659-65. PMID: 592556.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G1975

    Gestrinone

    Synthetic steroid hormone; AR agonist, ER and P...

    ≥98%
  • V3444

    Vilazodone

    5-HT1A partial agonist, SERT inhibitor.

    ≥98%
  • A4933

    Amifostine Trihydrate

    Thiol prodrug, antioxidant.

    ≥98%
  • C0247

    Calcineurin Autoinhibitory Peptide

    Peptide; calcineurin inhibitor.

    ≥95%
  • P327212

    Pifithrin-α-cyclic Hydrobromide

    p53 inhibitor

    ≥98%
  • H1673

    Hesperidin

    Flavonoid found in species of Citrus; COX-2 inh...

    ≥95%
  • T0077

    Transactivator of Transcription Peptide (2-4)

    Peptide, contains two cell-penetrating sequence...

    ≥95%
  • D0025

    DAMGO

    Synthetic peptice; μOR agonist.

    ≥95%
  • I2056

    Ifosfamide

    Nitrogen mustard, DNA alkylator.

    ≥98%
  • R3222

    Rifamycin SV Monosodium

    Ansamycin; bacterial DNA-dependent RNA polymera...

    ≥98%
  • M0262

    Maprotiline Hydrochloride

    Tetracycline; FIASMA, histamine H1, 5-HT2, mACh...

    ≥98%
  • W2933

    WHI-P131

    JAK3 and EGFR inhibitor.

    ≥99%
  • P1849

    Pemetrexed Disodium

    Thymidylate synthase inhibitor, potential SHMT,...

    ≥98%
  • O7377

    Osthole

    O-methylated coumarin; Ca2+ channel blocker.

    ≥98%
  • D1770

    Dermorphin Analog

    Synthetic peptide; dermorphin analog; δOR and ...

    ≥95%
  • R2812

    Recombinant HIV-1 gp-120

    Recombinant HIV glycoprotein antigen fragment.<...

    ≥95%
  • O4578

    Oltipraz

    Antioxidant; Nrf2 activator.

    ≥98%
  • H5748

    D,L-Homocysteine Thiolactone Hydrochloride

    Heterocyclic derivative of cysteine, alters pro...

    ≥99%
  • N1755

    Neomycin Sulfate

    Polycationic aminoglycoside; protein translatio...

    ≥98%
  • A4944

    Amlexanox

    Azoxanthone derivative; S100A12 and S100A13 inh...

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only