• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Mecamylamine Hydrochloride

Mecamylamine Hydrochloride

Product ID M1708
Cas No. 826-39-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $77.70 In stock
25 mg $281.60 In stock
100 mg $901.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Mecamylamine is a reversible, non-competitive, non-selective inhibitor of nicotinic acetylcholine receptors (nAChRs); it decreases channel open time and burst duration. This compound exhibits antihypertensive, antidepressant, and anxiolytic activities. Mecamylamine crosses the blood-brain barrier and acts both centrally and peripherally, resulting in high incidence of peripheral side effects. Mecamylamine was previously clinically used to decrease blood pressure, but also reduces mood instability and depression in subjects with Tourette’s syndrome and shows potential benefit as a smoking cessation therapy. In animals, mecamylamine improves activity in the forced swim test, social interaction tests, and light/dark paradigms.

Product Info

Cas No.

826-39-1

Purity

≥98%

Formula

C11H21N • HCl

Formula Wt.

203.75

IUPAC Name

N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine;hydrochloride

Synonym

inversine, 2-(methylamino)isocamphane hydrochloride, N,2,3,3-tetramethyl-2-norbornanamine, N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride

Melting Point

245.5-246.5°C (dec)

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M1708 MSDS PDF

Info Sheet

M1708 Info Sheet PDF

References

Peng C, Kimbrell MR, Tian C, et al. Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents. Mol Pharmacol. 2013 Sep;84(3):459-75. PMID: 23839567.

Sanberg PR, Vindrola-Padros C, Shytle RD. Translating laboratory discovery to the clinic: from nicotine and mecamylamine to Tourette's, depression, and beyond. Physiol Behav. 2012 Dec 5;107(5):801-8. PMID: 22776623.

LeSage MG, Shelley D, Pravetoni M, et al. Enhanced attenuation of nicotine discrimination in rats by combining nicotine-specific antibodies with a nicotinic receptor antagonist. Pharmacol Biochem Behav. 2012 Jul;102(1):157-62. PMID: 22503967.

Bacher I, Wu B, Shytle DR, et al. Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. Expert Opin Pharmacother. 2009 Nov;10(16):2709-21. PMID: 19874251.

Lippiello PM, Beaver JS, Gatto GJ, et al. TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity. CNS Neurosci Ther. 2008 Winter;14(4):266-77. PMID: 19040552.

Shytle RD, Penny E, Silver AA, et al. Mecamylamine (Inversine): an old antihypertensive with new research directions. J Hum Hypertens. 2002 Jul;16(7):453-7. PMID: 12080428.

Hayashi E, Yamada S, Mori M. Comparative studies on anti-nicotinic action of hexamethonium, mecamylamine and adenosine in the guinea pig isolated ileum. Jpn J Pharmacol. 1977 Oct;27(5):659-65. PMID: 592556.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P7012

    Prednisolone Sodium Phosphate

    Water-soluble cortisol derivative; glucocortico...

    ≥98%
  • C5968

    Cordycepin

    Nucleoside (deoxyadenosine) analog found in Co...

    ≥99%
  • T1854

    Tenofovir Monohydrate

    Nucleotide analog; RT inhibitor.

    ≥98%
  • S7601

    Statil

    Aldose reductase inhibitor.

    ≥98%
  • C4533

    Clindamycin Phosphate

    Lincosamide; ribosomal translocation and protei...

    ≥98%
  • F334453

    Filipin III

    Antifungal antibiotic

    ≥95%
  • P9869

    Pyridoxine Hydrochloride

    Vitamin B6 derivative, antioxidant.

    ≥98%
  • S8147

    Sulindac Sulfide

    NSAID; COX-1/2 and PDE inhibitor.

    ≥98%
  • D3223

    Difloxacin Hydrochloride

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • C9809

    Cyclopiazonic Acid

    SERCA inhibitor.

    ≥98%, TLC
  • E537332

    Enniatin A

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • M9368

    Myristicin

    Allylbenzene found in spices and umbelliferous ...

    ≥98%
  • V0376

    Vatalanib Dihydrochloride

    VEGFR inhibitor.

    ≥98%
  • L8276

    Luteinizing Hormone Releasing Hormone

    Endogenous peptide hormone; GnRH agonist.

    ≥98%
  • P2400

    Phenethyl Caffeate

    Found in propolis; 5-lipoxygenase inhibitor.

    ≥98%
  • A0248

    BAM-12P

    Peptide, cleavage product of proenkephalin; κO...

    ≥95%
  • H978583

    Hyoscyamine sulfate dihydrate

    Tropane alkaloid found in plants in the Solanac...

    ≥99%
  • T7676

    HT-2 Toxin

    Trichothecene mycotoxin produced by Fusarium.

    ≥98%, TLC, HPLC
  • T5996

    Tozasertib

    AurK, FLT3, Abl inhibitor.

    ≥98%
  • A8070

    Auraptene

    Monoterpene coumarin ether found in Citrus; PPA...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only