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Megestrol is a synthetic progestogen that exhibits orexigenic and anticancer chemotherapeutic activities. Megestrol is clinically used in the treatment of cachexia-anorexia to stimulate appetite and increase weight gain. In hepatocellular carcinoma models, megestrol induces G1 phase cell cycle arrest and apoptosis and decreases tumor volume.
| Cas No. | 595-33-5 |
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| Purity | ≥98% |
| Formula | C24H32O4 |
| Formula Wt. | 384.51 |
| Chemical Name | 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate |
| IUPAC Name | [(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12, 14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate |
| Synonym | Maygace, Megace, Megestil, Nia, Niagestin, Ovaban |
| Melting Point | 215-220°C |
| Solubility | Insoluble in water. Soluble in DMSO (33 mg/mL), ethanol (15 mg/mL). |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
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| Info Sheet |
Yeh SS, Lovitt S, Schuster MW. Usage of megestrol acetate in the treatment of anorexia-cachexia syndrome in the elderly. J Nutr Health Aging. 2009 May;13(5):448-54. PMID: 19390752.
Femia RA, Goyette RE. The science of megestrol acetate delivery: potential to improve outcomes in cachexia. BioDrugs. 2005;19(3):179-87. PMID: 15984902.
Zhang K, Chow PK. The effect of megestrol acetate on growth of HepG2 cells in vitro and in vivo. Clin Cancer Res. 2004 Aug 1;10(15):5226-32. PMID: 15297426.