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Melanoma antigen gene-encoding fragment MAGE-3 (271-279) is a peptide antigen presented by hepatocellular carcinoma cells in vitro and in vivo. MAGE-3 (271-279) could be targeted by epitope-specific CD8+ T cells in the development of an anticancer vaccine.
| Cas No. | 160295-81-8 |
|---|---|
| Purity | ≥95% |
| Formula | C53H79N13O10 |
| Formula Wt. | 1058.3 |
| IUPAC Name | L-Phenylalanyl-L-leucyl-L-tryptophylglycyl-L-prolyl-N5-(diaminomethylene)-L-ornithyl-L-alanyl-L-leucyl-L-valine |
| Synonym | MAGE-3 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet |
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Zhou M, Peng JR, Zhang HG, et al. Identification of two naturally presented MAGE antigenic peptides from a patient with hepatocellular carcinoma by mass spectrometry. Immunol Lett. 2005 Jun 15;99(1):113-21. PMID: 15885805.
Zerbini A, Pilli M, Soliani P, et al. Ex vivo characterization of tumor-derived melanoma antigen encoding gene-specific CD8+cells in patients with hepatocellular carcinoma. J Hepatol. 2004 Jan;40(1):102-9. PMID: 14672620.
Kanaoka S, Yamasaki S, Okino T, et al. Induction of human leukocyte antigen (HLA)-A2-restricted and MAGE-3-gene-derived peptide-specific cytolytic T lymphocytes using cultured dendritic cells from an HLA-A2 esophageal cancer patient. J Surg Oncol. 1999 May;71(1):16-21. PMID: 10362086.