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Meleagrin

Meleagrin

Product ID M174446
Cas No. 71751-77-4
Purity ≥99%
Product Unit SizeCostQuantityStock
0.1 mg $38.00 In stock
100 µg $54.50 In stock
1 mg $286.10 In stock
5 mg $1,144.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Meleagrin is an indole alkaloid isolated from the fungus Penicillium chrysogenum. This FabI inhibiting antibiotic has also been found to have anti-tumor activities in various cell lines.

Product Info

Cas No.

71751-77-4

Purity

≥99%

Formula

C23H23N5O4

Formula Wt.

433.47

Chemical Name

(3E,7aS,12aR)-6-Hydroxy-3-(1H-imidazol-4-ylmethylene)-12-methoxy-7a-(2-methyl-3-buten-2-yl)-7a,12-dihydro-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dione

IUPAC Name

(3E,7aS,12aR)-6-Hydroxy-3-(1H-imidazol-4-ylmethylene)-12-methoxy-7a-(2-methyl-3-buten-2-yl)-7a,12-dihydro-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dione

Synonym

Meleagrine;6-O-Methyloxaline, Meleagrine

Appearance

Light yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M174446 MSDS PDF

Info Sheet

M174446 Info Sheet PDF

References

García-Estrada C1, Ullán RV, Albillos SM, et al. A single cluster of coregulated genes encodes the biosynthesis of the mycotoxins roquefortine C and meleagrin in Penicillium chrysogenum. Chem Biol. 2011, 18(11):1499-512. doi: 10.1016/j.chembiol.2011.08.012. PMID: 22118684

Du L1, Feng T, Zhao B, et al. Alkaloids from a deep ocean sediment-derived fungus Penicillium sp. and their antitumor activities. J Antibiot (Tokyo). 2010 , 63(4):165-70. PMID: 20186171

Mady MS, Mohyeldin MM, Ebrahim HY, et al. The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion. Bioorg Med Chem. 2016, 15;24(2):113-22. PMID: 26692349.

Custom Order

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