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Methotrexate Hydrate

Methotrexate Hydrate

Product ID M1676
Cas No. 6745-93-3
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $54.20 In stock
50 mg $78.10 In stock
100 mg $117.70 In stock
500 mg $213.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Methotrexate is an antimetabolite that exhibits immunosuppressive, abortifacient, anti-inflammatory, and anticancer chemotherapeutic activities. Methotrexate is clinically used to treat various cancers, ectopic pregnancy, and rheumatoid arthritis. Methotrexate inhibits dihydrofolate reductase, preventing thymidine, DNA, and RNA synthesis. In vivo, methotrexate increases T cell apoptosis, decreases T cell activation, and suppresses cytokine production.

Product Info

Cas No.

6745-93-3

Purity

≥98%

Formula

C20H22N8O5 • H2O

Formula Wt.

472.45

Chemical Name

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methyl- amino]benzoyl]-L-glutamic acid

IUPAC Name

(2S)-2-[[4-[(2, 4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid

Synonym

L-(+)-Amethopterin Dihydrate, Amethopterin, MTX, Emtexate, Ledertrexate, Rheumatrex

Melting Point

185-204°C(dec.)

Solubility

Not soluble in water or ethanol. Soluble in dilute HCl and in alkaline soln.

Appearance

Yellow Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M1676 MSDS PDF

Info Sheet

M1676 Info Sheet PDF

References

Herfarth HH, Long MD, Isaacs KL. Methotrexate: underused and ignored? Dig Dis. 2012;30 Suppl 3:112-8. doi: 10.1159/000342735. PMID: 23295701.

Mol F, Mol BW, Ankum WM, et al. Current evidence on surgery, systemic methotrexate and expectant management in the treatment of tubal ectopic pregnancy: a systematic review and meta-analysis. Hum Reprod Update. 2008 Jul-Aug;14(4):309-19. PMID: 18522946.

Wessels JA, Huizinga TW, Guchelaar HJ. Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis. Rheumatology (Oxford). 2008 Mar;47(3):249-55. PMID: 18045808.

Custom Order

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