• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Mevastatin

Mevastatin

Product ID M1685
Cas No. 73573-88-3
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $42.80 In stock
50 mg $162.30 In stock
250 mg $478.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Mevastatin is an HMG-CoA reductase inhibitor that exhibits anti-hyperlipidemic, anticancer, and immunomodulatory activities. Mevastatin induces apoptosis and inhibits growth of salivary adenoid cystic carcinoma cells by increasing cytochrome c release, activation of caspase 3, and phosphorylation of JNK, p38 MAPK, and ERK1/2. In other models, mevastatin inhibits bisphosphonate-induced activation of γδ T cells and release of TNF-α.

Product Info

Cas No.

73573-88-3

Purity

≥98%

Formula

C23H34O5

Formula Wt.

390.51

Chemical Name

(2S)-2-Methylbutanoic acid (1S,7S,8S,8aR)- 1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)- tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1- naphthalenyl ester

IUPAC Name

[(1S,7S,8S,8aR)-8-[2-[(2R, 4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8, 8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate

Synonym

Compactin, 6-demethylmevinolin, CS-500, ML-236B.

Melting Point

152°C

Solubility

Soluble in DMSO, or ethanol. Insoluble in water.

Appearance

White Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M1685 MSDS PDF

Info Sheet

M1685 Info Sheet PDF

Brochures

Statins Flyer

References

Zhang S, Wang XL, Gan YH, et al. Activation of c-Jun N-terminal kinase is required for mevastatin-induced apoptosis of salivary adenoid cystic carcinoma cells. Anticancer Drugs. 2010 Aug;21(7):678-86. PMID: 20629200.

Thompson K, Rogers MJ. Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro. J Bone Miner Res. 2004 Feb;19(2):278-88. PMID: 14969398.

Endo A, Kuroda M, Tsujita Y. ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium. J Antibiot (Tokyo). 1976 Dec;29(12):1346-8. PMID: 1010803.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D178589

    1-Deoxynojirimycin

    Anti-diabetic alkaloid

    ≥98%
  • D5612

    2-n-Dodecylfuran

    Furan derivative.

    ≥98%
  • H014458

    Halometasone

    Glucocorticoid

    ≥98%
  • A5285

    [Ile7]-Angiotensin III

    Peptide, derivative of AT III, cleavage product...

    ≥95%
  • S8145

    Sulindac

    NSAID; COX-1/2 and PDE inhibitor.

    ≥99%
  • R1777

    9-cis-Retinoic Acid

    Vitamin A derivative; RAR and RXR agonist.

    ≥99%
  • V3277

    Vitamin E

    Synthetic vitamin E, antioxidant.

    ≥98%
  • I0482

    S-(+)-Ibuprofen

    Optically active isomer of ibuprofen, NSAID; CO...

    ≥98%
  • G0044

    Galantide

    Peptide; galanin antagonist.

    ≥95%
  • A5279

    Angiotensin II (1-4), human

    Endogenous peptide fragment, involved in vasoco...

    ≥95%
  • V0269

    Vardenafil Dihydrochloride

    PDE5 inhibitor.

    ≥99%
  • S0048

    Salicin

    Alcoholic β-glucoside found in willow bark, sa...

    ≥98%
  • G8101

    Guaifenesin

    Expectorant.

    ≥98%
  • S5722

    Sofosbuvir

    Viral RNA polymerase inhibitor.

    ≥98%
  • K1655

    Kenpaullone

    GSK-3β, HGK, and CDK inhibitor.

    ≥95%
  • B6816

    Brefeldin A

    Lactone found in fungi such as Eupenicillium; g...

    ≥97%
  • Z4833

    ZM-336372

    c-Raf inhibitor, tyrosine kinase inhibitor.

    ≥98%
  • E7657

    Etoposide

    Podophyllotoxin derivative; topoisomerase II in...

    ≥98%
  • E2003

    Efavirenz

    Non-nucleoside RT inhibitor.

    ≥99%
  • J0379

    Jatrorrhizine Chloride

    Alkaloid compound originally found in Corydalis...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only