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Mevastatin is an HMG-CoA reductase inhibitor that exhibits anti-hyperlipidemic, anticancer, and immunomodulatory activities. Mevastatin induces apoptosis and inhibits growth of salivary adenoid cystic carcinoma cells by increasing cytochrome c release, activation of caspase 3, and phosphorylation of JNK, p38 MAPK, and ERK1/2. In other models, mevastatin inhibits bisphosphonate-induced activation of γδ T cells and release of TNF-α.
| Cas No. | 73573-88-3 |
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| Purity | ≥98% |
| Formula | C23H34O5 |
| Formula Wt. | 390.51 |
| Chemical Name | (2S)-2-Methylbutanoic acid (1S,7S,8S,8aR)- 1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)- tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1- naphthalenyl ester |
| IUPAC Name | [(1S,7S,8S,8aR)-8-[2-[(2R, 4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8, 8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate |
| Synonym | Compactin, 6-demethylmevinolin, CS-500, ML-236B. |
| Melting Point | 152°C |
| Solubility | Soluble in DMSO, or ethanol. Insoluble in water. |
| Appearance | White Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
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| Info Sheet | |
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Zhang S, Wang XL, Gan YH, et al. Activation of c-Jun N-terminal kinase is required for mevastatin-induced apoptosis of salivary adenoid cystic carcinoma cells. Anticancer Drugs. 2010 Aug;21(7):678-86. PMID: 20629200.
Thompson K, Rogers MJ. Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro. J Bone Miner Res. 2004 Feb;19(2):278-88. PMID: 14969398.
Endo A, Kuroda M, Tsujita Y. ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium. J Antibiot (Tokyo). 1976 Dec;29(12):1346-8. PMID: 1010803.