• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
MK-0752

MK-0752

Product ID M4200
Cas No. 471905-41-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $78.80 In stock
5 mg $236.30 In stock
25 mg $682.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

MK-0752 is a γ-secretase inhibitor that suppresses Notch signaling and exhibits neuroprotective and anticancer chemotherapeutic activities. This compound decreases the formation of amyloid-β (Aβ) plaques. MK-0752 is in clinical trials as a potential treatment for brain and CNS-centric cancers.

Product Info

Cas No.

471905-41-6

Purity

≥98%

Formula

C21H21ClF2O4S

Formula Wt.

442.90

IUPAC Name

3-{cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl}propanoic acid

Solubility

DMSO 89 mg/mL (200.94 mM) Ethanol 45 mg/mL (101.6 mM) Water Insoluble

Appearance

Yellow crystal powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M4200 MSDS PDF

Info Sheet

M4200 Info Sheet PDF

References

Hoffman LM, Fouladi M, Olson J, et al. Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study. Childs Nerv Syst. 2015 Aug;31(8):1283-9. PMID: 25930724.

Olson RE, Albright CF. Recent progress in the medicinal chemistry of gamma-secretase inhibitors. Curr Top Med Chem. 2008;8(1):17-33. PMID: 18220929.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • H9661

    Hypocrellin A

    Prevents MHC II antigen presentation.

    ≥77%, contains ~16% B
  • A4933

    Amifostine Trihydrate

    Thiol prodrug, antioxidant.

    ≥98%
  • A3208

    AICAR

    AMPK activator.

    ≥98%
  • P333400

    PIK-75

    p110α inhibitor.

    ≥99%
  • P0049

    Pamidronate Disodium Pentahydrate

    Bisphosphonate.

    ≥98%
  • P7158

    Protopine

    Isoquinoline alkaloid found in a variety of pla...

    ≥98%
  • L930280

    LXH254

    pan-RAF inhibitor

    ≥99%
  • S680017

    SR-717 Lithium Salt

    STING agonist

    ≥98%
  • A1319

    Adenosine Triphosphate Disodium Hydrate

    Endogenous coenzyme, unit of cellular energy, r...

    ≥95%
  • O4658

    Olopatadine Hydrochloride

    Mast cell stabilizer; histamine H1/2/3 antagoni...

    ≥99%
  • T0152

    Tandutinib

    FLT3, PDGFR, c-Kit inhibitor.

    ≥98%
  • T1014

    7-TES-Paclitaxel

    Synthesis impurity

    ≥95%
  • K0133

    Kainic Acid

    Excitatory amino acid found in seaweed; AMPA an...

    ≥98%
  • G5216

    GNE-7915

    LRRK2 inhibitor.

    ≥98%
  • T1855

    Tentoxin

    Cyclic peptide mycotoxin produced by Alternaria...

    ≥98%, HPLC
  • C1648

    α-Cembrenediol

    Diterpene found in Anisomeles.

    ≥99%
  • W0270

    (±)-Warfarin Sodium Clathrate

    Coumarin; VKORC1 inhibitor.

    ≥98%
  • T7036

    Triptorelin

    Peptide, GnRH analog; GnRH agonist.

    ≥98%
  • A7204

    AS-605240

    p110δ PI3K inhibitor.

    ≥98%
  • B1876

    Betamethasone

    Steroid; glucocorticoid agonist.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only