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MK-0752

MK-0752

Product ID M4200
Cas No. 471905-41-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $78.80 In stock
5 mg $236.30 In stock
25 mg $682.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

MK-0752 is a γ-secretase inhibitor that suppresses Notch signaling and exhibits neuroprotective and anticancer chemotherapeutic activities. This compound decreases the formation of amyloid-β (Aβ) plaques. MK-0752 is in clinical trials as a potential treatment for brain and CNS-centric cancers.

Product Info

Cas No.

471905-41-6

Purity

≥98%

Formula

C21H21ClF2O4S

Formula Wt.

442.90

IUPAC Name

3-{cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl}propanoic acid

Solubility

DMSO 89 mg/mL (200.94 mM) Ethanol 45 mg/mL (101.6 mM) Water Insoluble

Appearance

Yellow crystal powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M4200 MSDS PDF

Info Sheet

M4200 Info Sheet PDF

References

Hoffman LM, Fouladi M, Olson J, et al. Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study. Childs Nerv Syst. 2015 Aug;31(8):1283-9. PMID: 25930724.

Olson RE, Albright CF. Recent progress in the medicinal chemistry of gamma-secretase inhibitors. Curr Top Med Chem. 2008;8(1):17-33. PMID: 18220929.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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