• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
MK-2461

MK-2461

Product ID M4004
Cas No. 917879-39-1
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $114.60 In stock
5 mg $354.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

MK-2461 is an inhibitor of MET that also shows inhibition of FGFR and PDGFR. In animal models of glioblastoma and gastric cancer, MK-2461 exhibits anticancer chemotherapeutic activity, decreasing tumor growth and size.

Product Info

Cas No.

917879-39-1

Purity

≥99%

Formula

C24H25N5N5S

Formula Wt.

495.55

Chemical Name

9-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine

IUPAC Name

9-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine

Synonym

MK2461

Solubility

DMSO 99 mg/mL (199.77 mM) Water Insoluble Ethanol Insoluble

Appearance

Yellow Solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M4004 MSDS PDF

Info Sheet

M4004 Info Sheet PDF

References

Katz JD, Jewell JP, Guerin DJ, et al. Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer. J Med Chem. 2011 Jun 23;54(12):4092-108. PMID: 21608528.

Pan BS, Chan GK, Chenard M, et al. MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33. PMID: 20145145.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A7204

    AS-605240

    p110δ PI3K inhibitor.

    ≥98%
  • D3262

    Dipropyl Sulfide

    Organosulfide found in Allium; cholesterol synt...

    ≥99%
  • N5669

    Nordihydroguaiaretic Acid

    Phenol found in the creosote bush; 5-lipoxygena...

    ≥99%
  • Z7477

    ZSTK474

    PI3K inhibitor.

    ≥98%
  • M0273

    Mastoparan 8

    Antimicrobial peptide found in bee and wasp ven...

    ≥95%
  • E0001

    E64

    Cysteine protease inhibitor.

    ≥99%
  • N5767

    Norethindrone

    Steroid hormone, contraceptive; PR agonist.

    ≥98%
  • P0144

    Paliperidone

    D2 and 5-HT2A antagonist.

    ≥97%
  • T2933

    4-Thiouridine

    Modified nucleotide used for labeling DNA; DNA ...

    ≥99%
  • T8020

    Tuftsin

    Tetrapeptide, IgG Fc region derivative; Nrp1 ag...

    ≥95%
  • P9200

    PX-866

    Wortmannin analog; PI3K inhibitor.

    ≥98%
  • I5992

    IOX2

    Prolyl hydroxylase inhibitor.

    ≥98%
  • P200097

    PF-06821497

    EZH2 inhibitor

    ≥99%
  • A0968

    Adrenocorticotropic Hormone (1-24), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • A5285

    [Ile7]-Angiotensin III

    Peptide, derivative of AT III, cleavage product...

    ≥95%
  • F1745

    Felodipine

    Dihydropyridine; L-type Ca2+ channel blocker.

    ≥98%
  • I7356

    Isopropyl Thiogalactoside

    Galactose analog, allolactose mimic, induces ac...

    ≥98%
  • C0274

    Caspofungin Diacetate

    Lipopeptide; 1,3-β-Glucan synthase inhibitor.<...

    ≥95%
  • L8377

    Luteolin

    Flavonoid found in various plant sources; DAT a...

    ≥95%
  • J0001

    J-147

    Phenyl hydrazide; neuronal oxidative stress inh...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only