Description
MK-2461 is an inhibitor of MET that also shows inhibition of FGFR and PDGFR. In animal models of glioblastoma and gastric cancer, MK-2461 exhibits anticancer chemotherapeutic activity, decreasing tumor growth and size.
Product Unit Size | Cost | Quantity | Stock |
---|
MK-2461 is an inhibitor of MET that also shows inhibition of FGFR and PDGFR. In animal models of glioblastoma and gastric cancer, MK-2461 exhibits anticancer chemotherapeutic activity, decreasing tumor growth and size.
Cas No. | 917879-39-1 |
---|---|
Purity | ≥99% |
Formula | C24H25N5N5S |
Formula Wt. | 495.55 |
Chemical Name | 9-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine |
IUPAC Name | 9-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine |
Synonym | MK2461 |
Solubility | DMSO 99 mg/mL (199.77 mM) Water Insoluble Ethanol Insoluble |
Appearance | Yellow Solid |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Katz JD, Jewell JP, Guerin DJ, et al. Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer. J Med Chem. 2011 Jun 23;54(12):4092-108. PMID: 21608528.
Pan BS, Chan GK, Chenard M, et al. MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33. PMID: 20145145.
Flavanol originally found in Camilla (green tea...
Benzothiazepine; L-type Ca2+ channel blocker, p...
Diterpene found in Taxus; potential microtubule...
mAChR antagonist.
Peptide, derivative of AT II, involved in vasoc...
nNOS inhibitor.
Bisphosphonate.
Thio sulforaphane analog, ITC.
Peptide; galanin antagonist.
Endogenous peptide, involved in immune signalin...
Flavonoid glycoside found in Pyrola.
Polymixin, antimicrobial peptide, induces forma...
ITC found in cruciferous vegetables.
Endogenous peptide hormone inolved in gastric e...
FIASMA; α1- and β1/2-adrenergic antagonist.
Aspirin analog; hemoglobin chain cross-linker.<...
Calcineurin inhibitor.
Nucleoside (guanosine) analog; DNA chain termin...
Endogenous peptide hormone, somatostatin analog...
EGFR2 inhibitor.