Description
MRTX113 is a potent and selective inhibitor of KRASG12D protein.
MRTX1133
Product ID M704789
Cas No. 2621928-55-8
Purity ≥98%
| Product Unit Size | Cost | Quantity | Stock |
|---|
Product Info
| Cas No. | 2621928-55-8 |
|---|---|
| Purity | ≥98% |
| Formula | C33H31F3N6O2 |
| Formula Wt. | 600.65 |
| IUPAC Name | 4-[4-(3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-[[(2R,8S)-2-fluoro-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoronaphthalen-2-ol |
| Synonym | NSC-836407 |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
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References
Issahaku A, Mukelabai N, Agoni C, et al. Characterization of the binding of MRTX1133 as an avenue for the discovery of potential KRASG12D inhibitors for cancer therapy. Sci Rep. 2022 Oct 22;12(1):17796. PMID: 36273239
Hallin J, Bowcut V, Calinisan A, et al. Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor. Nat Med. 2022 Oct;28(10):2171-2182. PMID: 36216931
Wang X, Allen S, Blake J, et al. Identification of MRTX1133, a noncovalent, potent, and selective KRASG12D inhibitor. J Med Chem. 2022 Feb 24;65(4):3123-3133. PMID: 34889605