Description
MRTX113 is a potent and selective inhibitor of KRASG12D protein.
| Product Unit Size | Cost | Quantity | Stock |
|---|
MRTX113 is a potent and selective inhibitor of KRASG12D protein.
| Cas No. | 2621928-55-8 |
|---|---|
| Purity | ≥98% |
| Formula | C33H31F3N6O2 |
| Formula Wt. | 600.65 |
| IUPAC Name | 4-[4-(3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-[[(2R,8S)-2-fluoro-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoronaphthalen-2-ol |
| Synonym | NSC-836407 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Issahaku A, Mukelabai N, Agoni C, et al. Characterization of the binding of MRTX1133 as an avenue for the discovery of potential KRASG12D inhibitors for cancer therapy. Sci Rep. 2022 Oct 22;12(1):17796. PMID: 36273239
Hallin J, Bowcut V, Calinisan A, et al. Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor. Nat Med. 2022 Oct;28(10):2171-2182. PMID: 36216931
Wang X, Allen S, Blake J, et al. Identification of MRTX1133, a noncovalent, potent, and selective KRASG12D inhibitor. J Med Chem. 2022 Feb 24;65(4):3123-3133. PMID: 34889605
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