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N-Acetyl-D-Leucine

N-Acetyl-D-Leucine

Product ID A0921
Cas No. 19764-30-8
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $71.70 In stock
1 g $113.40 In stock
5 g $380.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

N-acetyl-D-leucine is a D-amino acid that is deacylated in bacteria by d-aminoacylase enzymes. D-amino acids inhibit bacterial biofilm formation when they are incorporated into the cell wall. Compounds such as N-acetyl-D-leucine induce release of amyloid fibers that link cells together in the biofilm. N-Acetyl-leucine metabolite is found to be a biomarker that can predict diabetes development in a mouse model.

Product Info

Cas No.

19764-30-8

Purity

≥98%

Formula

C8H15NO3

Formula Wt.

173.21

Chemical Name

(2R)-2-acetamido-4-methylpentanoic acid

IUPAC Name

(2R)-2-acetamido-4-methylpentanoic acid

Synonym

N-Acetyl-R-Leucine, Ac-D-Leu-OH

Melting Point

176-177°C

Appearance

White to off white crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A0921 MSDS PDF

Info Sheet

A0921 Info Sheet PDF

References

Churchill G, Strupp M, Galione A, et al. Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance. PLoS One. 2020 Feb 27;15(2):e0229585. PMID: 32108176.

Leiman SA, May JM, Lebar MD, et al. D-amino acids indirectly inhibit biofilm formation in Bacillus subtilis by interfering with protein synthesis. J Bacteriol. 2013 Dec;195(23):5391-5. PMID: 24097941.

Kolodkin-Gal I, Romero D, Cao S, et al. D-amino acids trigger biofilm disassembly. Science. 2010 Apr 30;328(5978):627-9. PMID: 20431016.

Cummings JA, Fedorov AA, Xu C, et al. Annotating enzymes of uncertain function: the deacylation of D-amino acids by members of the amidohydrolase superfamily. Biochemistry. 2009 Jul 14;48(27):6469-81. PMID: 19518059.

Min J, Tomiyasu Y, Morotomi T, at al. First observation if N-acetyl leucine and N-acetyl isoleucine in diabetic patient hair and quantitative analysis by UPLC-ESI-MS/MS. Clin Chim Acta. 2015 Apr 15;444:143-148. PMID: 25687163.

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