LKT Labs

Biochemicals for Life Science Research

Nemorosone

Nemorosone

Product ID N176498
Cas No. 351416-47-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $52.50 In stock
5 mg $172.60 In stock
25 mg $525.90 In stock
100 mg $1,472.50 In stock
Bulk Quote

Quicklinks

Description

Nemorosone is one of the main bioactive compounds found in propolis produced by honey bees. Nemorosone is structurally related to hyperforin, but unlike hyperforin, nemorosone does not induce CYP3A4, making nemorosone the more viable option to develop a combination therapy targeting pancreatic cancer. In addition, nemorosone was found to inhibit growth, induce cell cycle arrest, abolish mitochondrial membrane potential, and elevate cytosolic calcium concentration in pancreatic cancer cells, and induce cytochrome c release and caspase-dependent apoptosis in cancer cells but not in fibroblasts. Furthermore, nemorosone has been shown to inhibit 17-beta-estradiol action, indicating that it may have potential therapeutic application to breast cancer.

Product Info

Cas No.

351416-47-2
Purity

≥99%
Formula

C33H42O4
Formula Wt.

502.70
Chemical Name

(1R,5R,7S)-5-benzoyl-2-hydroxy-6,6-dimethyl-1,3,7-tris(3-methylbut-2-enyl)bicyclo[3.3.1]non-2-ene-4,9-dione
IUPAC Name

(1R,5R,7S)-5-benzoyl-2-hydroxy-6,6-dimethyl-1,3,7-tris(3-methylbut-2-enyl)bicyclo[3.3.1]non-2-ene-4,9-dione
Synonym

Memorosone, 1-Benzoyl-3,5,7-tri-(3-methyl-2-butenyl)-4-hydroxy-8-dimethyl-bicyclo[3.3.1]-3-nonene-2,9-dione, 1-Benzoyl-4-hydroxy-8,8-dimethyl-3,5,7-tris-(3-methyl-but-2-enyl)-bicyclo[3.3.1]non-3-ene-2,9-dione, bicyclo[3.3.1]non-3-ene-2,9-dione, 1-benzoyl-4-hydroxy-8,8-dimethyl-3,5,7-tris(3-methyl-2-butenyl)-, (1R,5R,7S)-
Melting Point

66-68°C
Appearance

White crystalline solid (becomes yellow in solution when exposed to light and air).

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

N176498 MSDS PDF
Info Sheet

N176498 Info Sheet PDF

References

da Cunha MG, Rosalen PL, Franchin M, et al. Antiproliferative constituents of geopropolis from the bee Melipona scutellaris. Planta Med. 2016 Feb;82(3):190-194. PMID: 26544117.

Wolf RJ, Hilger RA, Hoheisel JD, et al. In vivo activity and pharmocokinetics of nemorosone in pancreatic cancer xenografts. PLoS One. 2013 Sep 5;8(9):e74555. PMID: 24040280.

Holtrup F, Bauer A, Fellenberg K, et al. Microarray analysis of nemorosone-induced cytotoxic effects on pancreatic cancer cells reveals activation of the unfolded protein response (UPR). Br J Pharmacol. 2011 Mar;162(5):1045-1059. PMID: 21091652.

Camargo MS, Prieto AM, Resende FA, et al. Evaluation of estrogenic, antiestrogenic and genotoxic activity of nemorosone, the major compound found in brown Cuban propolis. BMC Complement Altern Med. 2013 Jul 31;13:201. PMID: 23902919.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C3250

    Cimetidine

    Histamine H2 and AR antagonist, catalase inhibi...

    ≥99%
  • R2917

    Rhein

    Diacerein metabolite, anthraquinone found in Rh...

    ≥88%
  • T8145

    Tulobuterol Hydrochloride

    β2-adrenergic agonist.

    ≥98%
  • C3210

    Ciglitazone

    Thiazolidinedione; PPARγ agonist.

    ≥98%
  • A5037

    Amiodarone Hydrochloride

    Voltage-gated Na+, Ca2+, K+ channel blocker, α...

    ≥98%
  • S3568

    Siramesine

    σ2 agonist.

    ≥98%
  • A5193

    Amygdalin

    Glucoside found in stone fruits and apples.

    ≥98%
  • N1983

    Neuropeptide Y (3-36), human

    Endogenous peptide neurotransmitter, involved i...

    ≥95%
  • C4533

    Clindamycin Phosphate

    Lincosamide; ribosomal translocation and protei...

    ≥98%
  • E7556

    Etodolac

    NSAID; TRPA1 agonist, COX-2 inhibitor.

    ≥98%
  • L5751

    Lomerizine Dihydrochloride

    L-type and T-type Ca2+ and TRP antagonist.

    ≥98%
  • O446185

    Oleuropein

    Bioactive compound from olive tree.

    ≥98%
  • P6865

    Propranolol Hydrochloride

    β1/2-adrenergic antagonist.

    ≥98%
  • P2502

    Phenethyl Glucosinolate Potassium

    Found in cruciferous vegetables.

    ≥97%
  • T6903

    Tranylcypromine Hydrochloride

    MAO and histone demethylase LSD1 inhibitor.

    ≥98%
  • L960002

    LY-294002 Hydrochloride

    Inhibitor of PI3K.

    ≥98%
  • C4758

    Closantel Sodium

    Protonophore; chitinase OvCHT1 inhibitor.

    ≥98%
  • G3355

    Ginkgolide B

    Terpene lactone found in Ginkgo; GlyR antagonis...

    ≥98%
  • H9712

    (E)-4-Hydroxytamoxifen

    SERM.

    ≥97%
  • H9614

    Hydrochlorothiazide

    Thiazide diuretic; NCCT inhibitor, carbonic anh...

    ≥98%