• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Neomycin Sulfate

Neomycin Sulfate

Product ID N1755
Cas No. 1405-10-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $27.60 In stock
5 g $35.80 In stock
10 g $41.10 In stock
25 g $82.70 In stock
100 g $242.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Neomycin is a polycationic aminoglycoside antibiotic that exhibits antibacterial and neuromodulatory activities; it was originally found in species of Streptomyces. Neomycin binds to 23S rRNA, constraining tRNA in the P-site, inhibiting translocation and ribosomal recycling; together, this results in inhibition of protein synthesis. Neomycin B binds and inhibits bacterial RNase P and bacterial T box antiterminator RNA. Neomycin B inhibits mammalian RNA splicing as well. Neomycin also noncompetitively inhibits cation channels, including P2X receptors and transient receptor potential vanilloid receptor 1 (TRPV1) channels. Additionally, this compound inhibits Ca2+ influx, preventing presynaptic release of acetylcholine and norepinephrine in feline superior cervical ganglia.

Product Info

Cas No.

1405-10-3

Purity

≥98%

Formula

C23H46N6O13 • H2SO4

Formula Wt.

908.9

Chemical Name

5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[4-[3-amino-6-(aminomethyl)-4, 5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3- hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid

IUPAC Name

5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[4-[3-amino-6-(aminomethyl)-4, 5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3- hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid

Solubility

Soluble in water (1 g/mL).

Appearance

off-white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

N1755 MSDS PDF

Info Sheet

N1755 Info Sheet PDF

References

Wang L, Pulk A, Wasserman MR, et al. Allosteric control of the ribosome by small-molecule antibiotics. Nat Struct Mol Biol. 2012 Sep;19(9):957-63. PMID: 22902368.

Bongartz EV, Rettinger J, Hausmann R. Aminoglycoside block of P2X2 receptors heterologously expressed in Xenopus laevis oocytes. Purinergic Signal. 2010 Dec;6(4):393-403. PMID: 21437010.

Aukema KG, Chohan KK, Plourde GL, et al. Small molecule inhibitors of yeast pre-mRNA splicing. ACS Chem Biol. 2009 Sep 18;4(9):759-68. PMID: 19634919.

Anupam R, Denapoli L, Muchenditsi A, et al. Identification of neomycin B-binding site in T box antiterminator model RNA. Bioorg Med Chem. 2008 Apr 15;16(8):4466-70. PMID: 18329274.

Kawamoto SA, Sudhahar CG, Hatfield CL, et al. Studies on the mechanism of inhibition of bacterial ribonuclease P by aminoglycoside derivatives. Nucleic Acids Res. 2008 Feb;36(2):697-704. PMID: 18084035.

Raisinghani M, Premkumar LS. Block of native and cloned vanilloid receptor 1 (TRPV1) by aminoglycoside antibiotics. Pain. 2005 Jan;113(1-2):123-33. PMID: 15621372.

Wright JM, Collier B. The effects of neomycin upon transmitter release and action. J Pharmacol Exp Ther. 1977 Mar;200(3):576-87. PMID: 191590.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C4502

    Clarithromycin

    Macrolide; protein translation inhibitor.

    ≥95%
  • F4483

    Flufenamic Acid

    NSAID; TREK1 K+ potentiator, voltage-gated Na+ ...

    ≥97%
  • N3448

    Nimodipine

    L-type Ca2+ channel blocker.

    ≥98%
  • K624760

    KPT-276

    CRM1/XPO1 inhibitor.

    ≥99%
  • N3474

    Nisoldipine

    Calcium channel blocker.

    ≥98%
  • H9726

    Hygromycin B

    Protein translocation inhibitor.

    ≥95.0%
  • T1652

    Teniposide

    Podophyllotoxin derivative; topoisomerase II in...

    ≥97%
  • A1017

    Aceclofenac

    Diclofenac analog, NSAID; COX-2 inhibitor.

    ≥98%
  • T1006

    10-Acetoacetyl Paclitaxel

    Synthesis impurity

    ≥95%
  • C0270

    Carbamazepine

    GABA potentiator, voltage-gated Na+ and ATP-sen...

    ≥98%
  • S6018

    Spectinomycin Dihydrochloride Pentahydrate

    Aminocyclitol; protein synthesis inhibitor.

    ≥603 µg/mg (potency)
  • T1853

    Tenovin-6

    SIRT1/2 inhibitor, indirect p53 activator.

    ≥98%
  • G4662

    GLPG-0634

    JAK1 inhibitor.

    ≥98%
  • T4800

    TM3-0089 Sodium Monohydrate

    CRTH2 inhibitor.

    ≥98%
  • C0170

    N-(4-Carbethoxyphenyl)retinamide

    Retinoid, differentiation inducer.

    ≥98%
  • E6245

    Eplerenone

    Mineralocorticoid antagonist.

    ≥99%
  • O456505

    Olmutinib

    EGFR inhibitor.

    ≥98%
  • G5322

    GNF-5

    Abl inhibitor.

    ≥99%
  • N4974

    NMS-E628

    ALK and Ros1 inhibitor, Trk antagonist.

    ≥98%
  • A4521

    Alfacalcidol

    Vitamin D analog.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only