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Nicotinamide is an amide form of vitamin B3 that is incorporated into NAD and NADP as oxidation-reduction coenzymes. Nicotinamide exhibits anti-inflammatory and anxiolytic activities; it is clinically used to treat acne vulgaris and rosacea. Commercially, nicotinamide is used in skin whitening treatments as it decreases skin pigmentation. Nicotinamide also binds GABA receptors, decreasing aggressive behavior.
| Cas No. | 98-92-0 |
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| Purity | ≥98% |
| Formula | C6H6N2O |
| Formula Wt. | 122.12 |
| Chemical Name | 3-Pyridinecarboxylic acid amide |
| IUPAC Name | pyridine-3-carboxamide |
| Synonym | Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin PP, Vitamin B3 |
| Melting Point | 128-131°C |
| Solubility | Soluble in water (>600 mg/mL), ethanol (180 mg/mL), or glycerol. Insoluble in ether or acetone. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Navarrete-Solís J, Castanedo-Cázares JP, Torres-Álvarez B, et al. A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatol Res Pract. 2011;2011:379173. PMID: 21822427.
Niren NM. Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: a review. Cutis. 2006 Jan;77(1 Suppl):11-6. PMID: 16871774.
Akhundov RA, Sultanov AA, Gadzhily RA, et al. Psychoregulating role of nicotinamide. Biull Eksp Biol Med. 1993 May;115(5):487-91. PMID: 7913840.
Paul SM, Marangos PJ, Skolnick P, et al. Biological substrates of anxiety: benzodiazepine receptors and endogenous ligands. Encephale. 1982;8(2):131-44. PMID: 6125374.