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Nimustine is a nitrosourea compound that exhibits anticancer chemotherapeutic activity. Nimustine induces DNA cross-linking and double-stranded DNA breaks. This compound is clinically used to treat gliomas and may also downregulate expression of DNA ligase IV.
| Cas No. | 55661-38-6 |
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| Purity | ≥97% |
| Formula | C9H13ClN6O2 • HCl |
| Formula Wt. | 309.16 |
| Chemical Name | N'-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-(2- chloroethyl)-N-nitrosourea hydrochloride |
| IUPAC Name | 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1- nitrosourea;hydrochloride |
| Synonym | ACNU, Nidran  |
| Melting Point | 170-171°C |
| Solubility | Soluble in methanol and n-butanol. Soluble in water (100 mM) and DMSO (75 mM). (Practically insoluble in ethyl acetate, ether, chloroform and benzene. |
| Appearance | White or Slightly Yellow Crystalline Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Kondo N, Takahashi A, Mori E, et al. DNA ligase IV is a potential molecular target in ACNU sensitivity. Cancer Sci. 2010 Aug;101(8):1881-5. PMID: 20487264.
Kanamaru R, Asamura M, Sato H, et al. Studies on the mechanism of action of ACNU, 1-(4-amino-2-methylpyrimidine-5-yl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride: effects on cultured HeLa S3 cells. Tohoku J Exp Med. 1980 Dec;132(4):431-41. PMID: 6942530.