Description
Nitisinone is a nitrobenzene inhibitor of HPPD, an enzyme involved in tyrosine degradation. Nitisinone is clinically used to slow the effects of hereditary type 1 tyrosinemia and as a potential treatment for alkaptonuria.
Product Unit Size | Cost | Quantity | Stock |
---|
Nitisinone is a nitrobenzene inhibitor of HPPD, an enzyme involved in tyrosine degradation. Nitisinone is clinically used to slow the effects of hereditary type 1 tyrosinemia and as a potential treatment for alkaptonuria.
Cas No. | 104206-65-7 |
---|---|
Purity | ≥99% |
Formula | C14H10F3NO5 |
Formula Wt. | 329.23 |
IUPAC Name | 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione |
Synonym | NTBC, orfadin |
Solubility | DMSO: ≥5 mg/mL, Soluble in Chloroform |
Appearance | Light Yellow Powder |
Store Temp | 4°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
McKiernan PJ. Nitisinone in the treatment of hereditary tyrosinaemia type 1. Drugs. 2006;66(6):743-50. PMID: 16706549.
Kavana M, Moran GR. Interaction of (4-hydroxyphenyl)pyruvate dioxygenase with the specific inhibitor 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione. Biochemistry. 2003 Sep 2;42(34):10238-45. PMID: 12939152.
Phornphutkul C, Introne WJ, Perry MB, et al. Natural history of alkaptonuria. N Engl J Med. 2002 Dec 26;347(26):2111-21. PMID: 12501223.
FLT3, PDGFR inhibitor.
Phytoestrogen, flavonoid found in clover, soy, ...
Mycotoxin produced by Alternaria; oxidative pho...
Endogenous peptide hormone fragment, involved i...
Hydrophobic β-lactam; penicillin binding prote...
Mycotoxin produced by Alternaria; topoisomerase...
Triterpene sapogenin found in species of Panax;...
Steroid hormone, contraceptive; PR agonist.
NSAID; COX-2 inhibitor.
Pyrimidine nucleoside base, pairs with adenosin...
Kv7 K+ channel activator, NMDA antagonist, GABA...
Side chain attached to various taxanes.
Macrocyclic lactone.
JAK1/2 inhibitor.
Synthetic progestogen, orexigenic.
Topoisomerase II inhibitor, RPA modulator.
CDK2/4/6 inhibitor
Podophyllotoxin derivative; topoisomerase II in...
Pyrimidine, glucose analog, used to induce diab...
Endogenous neuropeptide hormone, involved in so...