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Nitisinone

Nitisinone

Product ID N3476
Cas No. 104206-65-7
Purity ≥99%
Product Unit SizeCostQuantityStock
10 mg $60.60 In stock
50 mg $234.40 In stock
250 mg $682.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nitisinone is a nitrobenzene inhibitor of HPPD, an enzyme involved in tyrosine degradation. Nitisinone is clinically used to slow the effects of hereditary type 1 tyrosinemia and as a potential treatment for alkaptonuria.

Product Info

Cas No.

104206-65-7

Purity

≥99%

Formula

C14H10F3NO5

Formula Wt.

329.23

IUPAC Name

2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione

Synonym

NTBC, orfadin

Solubility

DMSO: ≥5 mg/mL, Soluble in Chloroform

Appearance

Light Yellow Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

N3476 MSDS PDF

Info Sheet

N3476 Info Sheet PDF

References

McKiernan PJ. Nitisinone in the treatment of hereditary tyrosinaemia type 1. Drugs. 2006;66(6):743-50. PMID: 16706549.

Kavana M, Moran GR. Interaction of (4-hydroxyphenyl)pyruvate dioxygenase with the specific inhibitor 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione. Biochemistry. 2003 Sep 2;42(34):10238-45. PMID: 12939152.

Phornphutkul C, Introne WJ, Perry MB, et al. Natural history of alkaptonuria. N Engl J Med. 2002 Dec 26;347(26):2111-21. PMID: 12501223.

Custom Order

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