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NMS-873

NMS-873

Product ID N4972
Cas No. 1418013-75-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $97.70 In stock
5 mg $147.00 In stock
25 mg $616.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

NMS-873 inhibits valosin-containing protein (VCP; p97/Cdc48p), an ATPase involved in endoplasmic reticulum-associated degradation. NMS-873 displays anticancer activity, activating the unfolded protein response, interfering with autophagy, and inducing cell death in cancer cells.

Product Info

Cas No.

1418013-75-8

Purity

≥98%

Formula

C27H28N4O3S2

Formula Wt.

520.67

IUPAC Name

3-[3-(Cyclopentylsulfanyl)-5-({[2-methyl-4'-(methylsulfonyl)-4-biphenylyl]oxy}methyl)-4H-1,2,4-triazol-4-yl]pyridine

Synonym

NMS873

Solubility

DMSO Solubility: 100 mg/mL (192.06 mM)

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N4972 MSDS PDF

Info Sheet

N4972 Info Sheet PDF

References

Chou TF, Bulfer SL, Weihl CC, et al. Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. J Mol Biol. 2014 Jul 29;426(15):2886-99. PMID: 24878061.

Magnaghi P, D'Alessio R, Valsasina B, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9(9):548-56. PMID: 23892893.

Custom Order

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