• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
NMS-873

NMS-873

Product ID N4972
Cas No. 1418013-75-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $97.70 In stock
5 mg $147.00 In stock
25 mg $616.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

NMS-873 inhibits valosin-containing protein (VCP; p97/Cdc48p), an ATPase involved in endoplasmic reticulum-associated degradation. NMS-873 displays anticancer activity, activating the unfolded protein response, interfering with autophagy, and inducing cell death in cancer cells.

Product Info

Cas No.

1418013-75-8

Purity

≥98%

Formula

C27H28N4O3S2

Formula Wt.

520.67

IUPAC Name

3-[3-(Cyclopentylsulfanyl)-5-({[2-methyl-4'-(methylsulfonyl)-4-biphenylyl]oxy}methyl)-4H-1,2,4-triazol-4-yl]pyridine

Synonym

NMS873

Solubility

DMSO Solubility: 100 mg/mL (192.06 mM)

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N4972 MSDS PDF

Info Sheet

N4972 Info Sheet PDF

References

Chou TF, Bulfer SL, Weihl CC, et al. Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. J Mol Biol. 2014 Jul 29;426(15):2886-99. PMID: 24878061.

Magnaghi P, D'Alessio R, Valsasina B, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9(9):548-56. PMID: 23892893.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • H9613

    N-(4-Hydroxyphenyl)retinamide

    Retinol (vitamin A) analog, binds RBP4; Des1 in...

    ≥98%
  • V0274

    [Lys8]-Vasopressin

    Peptide, vasopressin analog; V1/2 agonist.

    ≥95%
  • M7530

    [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone

    Semi-synthetic peptide, melanocortin analog; MC...

    ≥98%
  • C5592

    CNX-774

    BTK inhibitor.

    ≥98%
  • G3358

    Ginkgolide ABC

    Mixture of Ginkgolides A, B and C, found in Gin...

    ≥98%
  • C1621

    CEF4

    Peptide, vSrc-induced cytokine.

    ≥95%
  • G4581

    Glucosamine Sulfate Potassium Chloride

    Endogenous amino acid sugar involved in cartila...

    ≥98%
  • T3031

    Thienylbutyl Isothiocyanate

    ITC.

    ≥96%
  • D0182

    Daunorubicin Hydrochloride

    Anthracycline, DNA intercalator; topoisomerase ...

    ≥98%
  • R3197

    Rhynchophylline

    Oxyindole alkaloid found in Uncaria sinensis; h...

    ≥98%
  • G823720

    Gusacitinib

    SYK/JAK inhibitor

    ≥98%
  • A9818

    Azelastine Hydrochloride

    TRPV1 agonist, histamine H1 antagonist.

    ≥98%
  • O6932

    Oridonin

    Diterpenoid found in Rabdosia rubescens; potent...

    ≥98%
  • G5752

    Gonadorelin Acetate

    Synthetic peptide, GnRH derivative; GnRH agonist.
    ≥95%
  • L283720

    Losartan Carboxylic acid

    Active metabolite of losartan

    ≥ 99%
  • C1632

    Cefotaxime Acid

    β-lactam cephalosporin; penicillin binding pro...

    ≥91%
  • O9334

    Oxibendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • E7378

    Estrone

    Endogenous steroid hormone, estriol precursor; ...

    ≥97%
  • P6956

    Prostaglandin E1

    Endogenous prostaglandin, vasodilator.

    ≥98%
  • A965121

    AZD-5438

    Inhibitor of CDK.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only