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Nonactin

Nonactin

Product ID N5652
Cas No. 6833-84-7
Purity ≥95%, TLC
Product Unit SizeCostQuantityStock
1 mg $53.70 In stock
5 mg $107.30 In stock
10 mg $193.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nonactin is a neutral cyclic ionophore that acts as an alkali metal ion carrier, transporting cargo such as Na+, K+, and NH4+ across lipid bilayers. Nonactin is a macrotetrolide antibiotic, although it does not exhibit antibacterial activity. Nonactin is naturally found in species of Streptomyces. This ionophore suppresses intracellular glycosylation and inhibits several trafficking pathways in virus-infected cells. Nonactin also uncouples oxidative phosphorylation in mitochondria.

Product Info

Cas No.

6833-84-7

Purity

≥95%, TLC

Formula

C40H64O12

Formula Wt.

736.93

IUPAC Name

(1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone

Melting Point

145-148°C

Solubility

methanol, dichloromethane, ethyl acetate, DMSO

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

N5652 MSDS PDF

Info Sheet

N5652 Info Sheet PDF

References

Lee JM, Kim JG, Kim TH, et al. Nonactin hinders intracellular glycosylation in virus-infected baby hamster kidney cells. Mol Med Rep. 2010 Jan-Feb;3(1):115-9. PMID: 21472209.

Bala S, Kombrabail MH, Prabhananda BS. Effect of phloretin on ionophore mediated electroneutral transmembrane translocations of H(+), K(+) and Na(+) in phospholipid vesicles. Biochim Biophys Acta. 2001 Feb 9;1510(1-2):258-69. PMID: 11342163.

Vareille G, Marion P, Kraus JL, et al. Sodium transport by an ionizable and a neutral mobile carrier: effects of membrane structure on the apparent activation energy. Biochim Biophys Acta. 1993 Feb 23;1146(1):25-37. PMID: 8443224.

Ginsburg H, Stark G. Facilitated transport of di- and trinitrophenolate ions across lipid membranes by valinomycin and nonactin. Biochim Biophys Acta. 1976 Dec 14;455(3):685-700. PMID: 1036715.

Custom Order

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