LKT Labs

Biochemicals for Life Science Research

OTSSP167 Hydrochloride

Product ID O783743
Cas No. 1431698-10-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $73.80 In stock
5 mg $255.20 In stock
25 mg $793.80 In stock
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Description

OTSSP167 inhibits maternal embryonic leucine zipper kinase (MELK). MELK has been identified as a possible therapeutic target for breast cancer, and is highly upregulated in other cancer types. OTSSP167 suppresses mammosphere formation of breast cancer cells and tumor growth in xenograft studies. In epithelial ovarian cancer, treatment with OTSSP167 reduced cell proliferation through G2/M cell cycle arrest resulting in apoptosis, even in cisplatin-resistant and paclitaxel-resistant cancer cells.

Product Info

Cas No.

1431698-10-0
Purity

≥98%
Formula

C25H29Cl3N4O2
Formula Wt.

523.88
IUPAC Name

1-[6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]ethanone;hydrochloride
Synonym

OTS167 Hydrochloride; OTSSP167 (hydrochloride); OTSSP167 HCL

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

O783743 MSDS PDF
Info Sheet

O783743 Info Sheet PDF

References

Chung S., Suzuki H., et al. Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget. (12):1629-40 (2012). PMID: 23283305.

Kholer R., Kettelhack H., et al. MELK expression in ovarian cancer correlates with poor outcome and its inhibition by OTSSP167 abrogates proliferation and viability of ovarian cancer cells. Gynecol Oncol. 145(1):159-166 (2017). PMID: 28214016.

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