Description
Paclitaxel Oxetane Ring-Opened 3-Acetyl 4-Benzoyl Impurity is an oxetane ring-opened impurity of Paclitaxel with no significant biological activity. It is also known as paclitaxel impurity M.
| Product Unit Size | Cost | Quantity | Stock |
|---|
Paclitaxel Oxetane Ring-Opened 3-Acetyl 4-Benzoyl Impurity is an oxetane ring-opened impurity of Paclitaxel with no significant biological activity. It is also known as paclitaxel impurity M.
| Cas No. | 932042-85-8 |
|---|---|
| Purity | ≥92% |
| Formula | C47H53NO15 |
| Formula Wt. | 871.92 |
| Chemical Name | β-(Benzoylamino)-α-hydroxybenzenepropanoic Acid (αR,βS)-(1S,3S,4S,4aR,5S,6S,8S,11R,12aS)-3,11-Bis(acetyloxy)-4-[(benzoyloxy)methyl]-1,2,3,4,4a,5,6,7,8,11,12,12a-dodecahydro-1,4,5,6-tetrahydroxy-9,12a,13,13-tetramethyl-12-oxo-6,10-methanobenzocyclodecen-8-yl Ester |
| IUPAC Name | [(1S,2S,3R,4S,5S,7S,8S,10R,13S)-5,10-bis(acetyloxy)-1,2,4,7-tetrahydroxy-13-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-8,12,15,15-tetramethyl-9-oxotricyclo[9.3.1.03,8]pentadec-11-en-4-yl]methyl benzoate |
| Synonym | Paclitaxel, Oxetane Ring Opened, Acetyl and Benzoyl Migrated; paclitaxel impurity M |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Nicolaou K, Yang Z, Liu J, et al. Total synthesis of taxol. Nature. 1994 Feb 17;367(6464):630-634. PMID: 7906395.
Nicolaou K, Valiulin R. Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents. Org Biomol Chem. 2013 Jul 7;11(25):4154-4163. PMID: 23685867.
Sanchez-Munoz R, Perez-Mata E, Almagro L, et al. A novel hydroxylation step in the taxane biosynthetic pathway: a new approach to paclitaxel production by synthetic biology. Front Bioeng Biotechnol. 2020 May 13;8::410. PMID: 32528936.
Guo B, Kai G, Jin H, et al. Taxol synthesis. African J Biotechnol. 2006 Jan 2;5(1):15-20.
Wang T, Chen Y, Zhuang W, et al. Transcriptome sequencing reveals regulatory mechanisms of taxol synthesis in Taxus wallichiana var. Mairei. Int J Genomics. 2019 May 2;2019:1596895. PMID: 31192250.
Cephalotaxine alkaloid originally found in Ceph...
Endogenous peptide, involved in paracrine and a...
Endogenous glycoprotein; lactoferrin agonist.
5-HT1A and σ1/2 agonist, 5-HT2A/2C/6/7, D1-4, ...
γ-Secretase inhibitor.
Peptide, GLP-1 analog found in Heloderma; GLP-1...
Prodrug
Peptide, derivative of AT II, involved in vasoc...
MAO and histone demethylase LSD1 inhibitor.
Endogenous sulfonic acid involved in Ca2+ signa...
H+/K+ ATPase inhibitor.
Antacid; pepsin inhibitor. Assay (Polysaccharid...
Triterpene sapongenin found in species of Panax...
NO donor; AR antagonist.
Pyrimidine nucleoside (cytidine) analog; DNA ch...
Kavalactone originally found in Piper methystic...
Flavanol originally found in Camilla (green tea...
EGFR inhibitor.