• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Palbociclib Hydrochloride

Palbociclib Hydrochloride

Product ID P0244
Cas No. 827022-32-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $45.30 In stock
5 mg $127.90 In stock
25 mg $375.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Palbociclib is an orally bioavailable selective inhibitor of CDK4 and CDK6, kinases that regulate cell cycle progression. This compound exhibits anticancer chemotherapeutic activity in a variety of models, including renal cell carcinoma and ER+ breast cancer. Palbociclib inhibits retinoblastoma phosphorylation, preventing cells from progressing from the G1 phase to the S phase and inducing apoptosis.

Product Info

Cas No.

827022-32-2

Purity

≥99%

Formula

C24H29N7O2 • HCl

Formula Wt.

483.99

IUPAC Name

6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one;hydrochloride

Synonym

PD-0332991

Solubility

Soluble in DMSO and water

Appearance

Yellow Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P0244 MSDS PDF

Info Sheet

P0244 Info Sheet PDF

References

Logan JE, Mostofizadeh N, Desai AJ, et al. PD-0332991, a Potent and Selective Inhibitor of Cyclin-dependent Kinase 4/6, Demonstrates Inhibition of Proliferation in Renal Cell Carcinoma at Nanomolar Concentrations and Molecular Markers Predict for Sensitivity. Anticancer Res. 2013 Aug;33(8):2997-3004. PMID: 23898052.

Roberts PJ, Bisi JE, Strum JC, et al. Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy. J Natl Cancer Inst. 2012 Mar 21;104(6):476-87. PMID: 22302033.

Rivadeneira DB, Mayhew CN, Thangavel C, et al. Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells. Gastroenterology. 2010 May;138(5):1920-30. PMID: 20100483.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L1684

    Levonorgestrel

    Synthetic progestogen; contraceptive.

    ≥98%
  • M5877

    Motesanib Diphosphate

    VEGFR, PDGFR, c-Kit, RET inhibitor.

    ≥98%
  • C5654

    Concanavalin A

    Lectin found in Canavelia, plant mitogen that b...

  • U6856

    Urocortin II, human

    Endogenous peptide, involved in stress signaling; ...
    ≥95%
  • N3474

    Nisoldipine

    Calcium channel blocker.  
    ≥98%
  • O4533

    Oligomycin

    Mixture of oligomycins A, B, C; oxidative phosp...

    ≥97%
  • T1020

    n-Butyl Analog of Paclitaxel

    Fermentation impurity

    ≥95%
  • N1769

    Nerolidol, synthetic

    AChE inhibitor, F0F1-ATP synthase modulator.

    A mixture of cis and trans isomers, ≥96%
  • O486188

    Omeprazole Impurity F and G mixture

    Regioisomers

    ≥98%
  • G4598

    Glycyrrhizic Acid Ammonium Hydrate

    Triterpene glycoside found in Glycyrrhiza; 11β...

    ≥93%
  • O9596

    Oxybutynin Hydrochloride

    mAChR antagonist.  
    ≥98%
  • H9716

    (E,Z)-4-Hydroxytamoxifen

    Selective estrogen receptor modulator.

    ≥97%
  • P1917

    Phenylethyl 3-methylcaffeate

    Derivative of methyl caffeate, hydroxycinnamic ...

    ≥97%
  • P3348

    Pimecrolimus

    Calcineurin inhibitor, potential TRPV1 agonist....

    ≥99%
  • B1655

    S-(N-Benzylthiocarbamoyl)-L-cysteine

    Cysteine conjugate of benzyl isothiocyanate (BI...

    ≥98%
  • A7476

    Astaxanthin

    Carotenoid found in shrimp, salmon, and algae.<...

    ≥97%
  • P0346

    Palosuran Hydrochloride

    Urotensin II receptor antagonist.
  • A7332

    Asiatic Acid, 95%

    Triterpene aglycone originally found in Centell...

    ≥95%
  • R1780

    trans-Retinoic Acid

    Vitamin A carboxylic acid; RAR agonist.

    ≥98%
  • M1978

    S-(+)-Methoprene

    Juvenille insect growth hormone analog.

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only