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Palosuran is an inhibitor of the urotensin II receptor that exhibits anti-fibrotic activity. In animal models of pulmonary arterial hypertension (PAH), palosuran decreases artery and arteriole wall thickness. This compound may also prevent the development of lung fibrosis.
| Formula | C25H30N4O2 HCl |
|---|---|
| Formula Wt. | 454.99 |
| Synonym | ACT 058362, ACT-058362, ACT058362 |
| Ship Temp | Ambient |
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Pehlivan Y, Dokuyucu R, Demir T, et al. Palosuran treatment effective as bosentan in the treatment model of pulmonary arterial hypertension. Inflammation. 2014 Aug;37(4):1280-8. PMID: 24604341.
Onat AM, Turkbeyler IH, Pehlivan Y, et al. The efficiency of a urotensin II antagonist in an experimental lung fibrosis model. Inflammation. 2012 Jun;35(3):1138-43. PMID: 22205238.