Description
Paromomycin is an aminoglycoside antibiotic that inhibits cation channels such as PX2X receptors; it exhibits antibacterial, anti-parasitic, and anti-protozoal activities. Paromomycin is clinically used to treat leishmaniasis. This compound inhibits ribosomal recycling, binding to the large subunit of the ribosome and inhibiting interactions between the ribosome and ribosome recycling factor (RRF). Paromomycin also decreases the mitochondrial membrane potential and suppresses protein synthesis (inhibiting translocation of RNA).