Paromomycin Sulfate

Name: Paromomycin Sulfate
SKU: P0370
Availability: InStock

Product ID P0370

Cas No. 1263-89-4

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Paromomycin is an aminoglycoside antibiotic that inhibits cation channels such as PX2X receptors; it exhibits antibacterial, anti-parasitic, and anti-protozoal activities. Paromomycin is clinically used to treat leishmaniasis. This compound inhibits ribosomal recycling, binding to the large subunit of the ribosome and inhibiting interactions between the ribosome and ribosome recycling factor (RRF). Paromomycin also decreases the mitochondrial membrane potential and suppresses protein synthesis (inhibiting translocation of RNA).

Product Info

Cas No.	1263-89-4
Purity	≥98%
Formula	C₂₃H₄₅N₅O₁₄ • H₂SO₄
Formula Wt.	713.71
Chemical Name	D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1- >4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)- beta-D-ribofuranosyl-(1->5))-2-deoxy-, sulfate (salt)
IUPAC Name	(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R)-5-[(1R,3S,5R, 6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4, 5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4- hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric acid
Synonym	Aminosidin sulfate, Gabbroral, Aminoxidin, Farmiglucin, Humagel, Humatin, Pargonyl, Sinosid.
Solubility	Soluble in water (>100 mg/mL).

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	P0370 MSDS PDF
Info Sheet	P0370 Info Sheet PDF

References

Bongartz EV, Rettinger J, Hausmann R. Aminoglycoside block of P2X2 receptors heterologously expressed in Xenopus laevis oocytes. Purinergic Signal. 2010 Dec;6(4):393-403. PMID: 21437010.

Jhingran A, Chawla B, Saxena S, et al. Paromomycin: uptake and resistance in Leishmania donovani. Mol Biochem Parasitol. 2009 Apr;164(2):111-7. PMID: 19146886.

Borovinskaya MA, Pai RD, Zhang W, et al. Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nat Struct Mol Biol. 2007 Aug;14(8):727-32. PMID: 17660832.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Email
This field is for validation purposes and should be left unchanged.

Paromomycin Sulfate

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Irbesartan

A23187 Ca-Mg

Hydrolyzed Fumonisin B2

Gastrin I, human

Risperidone

Recombinant Multi-epitope Chimeric HIV Antigen 1

α-Calcitonin Gene Related Peptide, human

Dutasteride

Recombinant HIV-1 gp-120

Pseudolaric Acid B

Entecavir

MGCD-265 Analog

Carbetocin Acetate

Isoimperatorin

S-(N-Methylsulfinylbutylthiocarbamoyl)-glutathione

(E)-KPT-330

Pirarubicin

L-5-Hydroxytryptophan

Naphazoline Hydrochloride

Isoflurane

Footer