• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
PD-184352

PD-184352

Product ID P1200
Cas No. 212631-79-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $97.70 In stock
5 mg $142.80 In stock
25 mg $435.80 In stock
100 mg $1,352.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

PD-184352 is an anticancer chemotherapeutic MEK1/2 and Raf inhibitor that is particularly effective against cancers harboring B-Raf or RAS mutations such as V600E. PD-184352 enhances p53 accumulation and caspase activation, increases levels of pro-apoptotic Bim protein, and decreasing levels of cyclin D1, inducing cell cycle arrest and apoptosis in several cancer cell lines. This compound also induces tumor regression in animal models carrying lung tumors.

Product Info

Cas No.

212631-79-3

Purity

≥98%

Formula

C17H14ClF2IN2O2

Formula Wt.

478.66

Chemical Name

2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-benzamide

IUPAC Name

2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide

Synonym

CI-1040

Solubility

Soluble in DMSO

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P1200 MSDS PDF

Info Sheet

P1200 Info Sheet PDF

Brochures

Ras-Raf-MEK-ERK Pathway Booklet

References

Wickenden JA, Jin H, Johnson M, et al. Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM. Oncogene. 2008 Dec 4;27(57):7150-61. PMID: 18806830.

Lunghi P, Giuliani N, Mazzera L, et al. Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways. Blood. 2008 Sep 15;112(6):2450-62. PMID: 18583568.

Bain J, Plater L, Elliott M, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. PMID: 17850214.

Ji H, Wang Z, Perera SA, et al. Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models. Cancer Res. 2007 May 15;67(10):4933-9. PMID: 17510423.

Squires MS, Nixon PM, Cook SJ. Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1. Biochem J. 2002 Sep 1;366(Pt 2):673-80. PMID: 12069688.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A4497

    Alyssin Sulfone

    Naturally sourced ITC, sulfonyl analog of sulfo...

    ≥97%
  • P1634

    Peimine

    Steroidal alkaloid found in Fritillaria; TRPV1 ...

    ≥98%
  • P0932

    PCI-32765

    BTK and IL-2-inducible kinase inhibitor.  
    ≥99%
  • T7056

    Troglitazone

    Thiazolidinedione; PPARγ agonist, ATP-sensitiv...

    ≥97%
  • D3219

    Diflubenzuron

    Benzoylurea, insect growth regulator; chitin sy...

    ≥95%
  • P982691

    Pyridostatin Trifluoroacetate Salt

    G-quadruplex ligand; DNA breakage inducer.

    ≥95%
  • A4854

    β-Amyloid Peptide (1-42), rat

    Endogenous APP peptide cleavage product, primar...

    ≥95%
  • T1016

    Propyl Analog of Paclitaxel

    Fermentation impurity

    ≥95%
  • D1773

    Deshydroxy LY-411575

    γ-Secretase inhibitor.

    ≥98%
  • T3350

    Timolol Maleate

    β-adrenergic antagonist.

    ≥98%
  • K0088

    Kawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • P6958

    Protopanaxatriol

    Triterpene sapogenin found in species of Panax;...

    ≥95%
  • P200097

    PF-06821497

    EZH2 inhibitor

    ≥99%
  • N3577

    Nitidine Chloride

    Benzophenanthridine alkaloid; topoisomerase I i...

    ≥98%
  • A0002

    A66

    p110α PI3K inhibitor.

    ≥98%
  • C5600

    CO-1686

    EGFR (WT, T790M) inhibitor.

    ≥98%
  • L8377

    Luteolin

    Flavonoid found in various plant sources; DAT a...

    ≥95%
  • P6959

    Prothionamide

    Nicotinic acid derivative; InhA inhibitor.

    ≥98%
  • B8676

    BVT-2733

    11β-HSD1 inhibitor.

    ≥98%
  • R3586

    Rivastigmine Tartrate

    AChE and BChE inhibitor.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only