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Pentagastrin

Pentagastrin

Product ID P1955
Cas No. 5534-95-2
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $278.10 In stock
2 mg $358.50 In stock
5 mg $525.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Pentagastrin is a synthetic polypeptide that stimulates gastric acid secretion on the gastrointestinal tract in a cholinergic signaling-dependent manner. Pentagastrin inhibits motilin-induced contractions in the stomach in animal models. Pentagastrin also enhances gastric defense by increasing mucus gel thickness, mucosal blood flow, and pHi.

Product Info

Cas No.

5534-95-2

Purity

≥95%

Formula

C37H50N7O9S

Formula Wt.

768.79

Chemical Name

(3S)-4-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-2-[3-(2-methylpropoxycarbonylamino)propanoylamino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-oxobutanoic acid

IUPAC Name

4-[[(2R)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-[[(2R)-2-[[(2S)-3-(1H-indol-3-yl)-2-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoylamino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-oxobutanoic acid

Synonym

Gastrodiagnost, Pentagastrinum, Peptavlon, Petogasrin

Melting Point

229°C

Appearance

White to off-white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P1955 MSDS PDF

Info Sheet

P1955 Info Sheet PDF

References

Beckert S, Wolf SC, Farrahi F, et al. TGF-beta3 inhibits pentagastrin-stimulated gastric acid secretion in rats. Med Sci Monit. 2005 Mar;11(3):BR80-3. PMID: 15735558.

Yamamoto O, Matsunaga Y, Shiba Y, et al. Inhibition of motilin-induced phase III contractions by pentagastrin in Heidenhain pouch dogs. J Pharmacol Exp Ther. 1994 Dec;271(3):1471-6. PMID: 7996460.

Nishizaki Y, Guth PH, Kim G, et al. Pentagastrin enhances gastric mucosal defenses in vivo: luminal acid-dependent and independent effects. Am J Physiol. 1994 Jul;267(1 Pt 1):G94-104. PMID: 8048536.

Zwick R, Bowes KL, Daniel EE, et al. Mechanism of action of pentagastrin on the lower esophageal sphincter. J Clin Invest. 1976 Jun;57(6):1644-51. PMID: 932198.

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