• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Perifosine

Perifosine

Product ID P1969
Cas No. 157716-52-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $105.30 In stock
5 mg $182.50 In stock
10 mg $273.50 In stock
25 mg $629.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Perifosine is an alkylphospholipid analog that exhibits anticancer chemotherapeutic and anti-inflammatory activities. Perifosine directly inhibits Akt by binding at multiple sites. In macrophages, perifosine inhibits LPS-induced increases in TNF-α and ERK activation and activates AMPK. In colorectal cancer, hepatocellular carcinoma, and multiple myeloma cells, perifosine induces apoptosis and inhibits growth; in clinical settings, perifosine enhances the anticancer activity of other chemotherapeutics.

Product Info

Cas No.

157716-52-4

Purity

≥98%

Formula

C25H52NO4P

Formula Wt.

461.66

Chemical Name

(1,1-dimethylpiperidin-1-ium-4-yl) octadecyl phosphate

IUPAC Name

(1,1-dimethylpiperidin-1-ium-4-yl) octadecyl phosphate

Synonym

KRX-0401; 1,1-Dimethylpiperidin-1-ium-4-yl octadecyl phosphate; KRX0401; (1,1-dimethylpiperidin-1-ium-4-yl) octadecyl phosphate

Solubility

Soluble in water (45 mg/mL). Soluble in ethanol (45 mg/mL). Soluble in chloroform, methanol.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P1969 MSDS PDF

Info Sheet

P1969 Info Sheet PDF

Brochures

PI3K-Akt-mTORC Pathway Booklet

References

Gradziel CS, Wang Y, Stec B, et al. Cytotoxic amphiphiles and phosphoinositides bind to two discrete sites on the Akt1 PH domain. Biochemistry. 2014 Jan 28;53(3):462-72. PMID: 24383815.

Shen J, Liang L, Wang C. Perifosine inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α production via regulation multiple signaling pathways: new implication for Kawasaki disease (KD) treatment. Biochem Biophys Res Commun. 2013 Jul 26;437(2):250-5. PMID: 23806687.

Richardson PG, Eng C, Kolesar J, et al. Perifosine, an oral, anti-cancer agent and inhibitor of the Akt pathway: mechanistic actions, pharmacodynamics, pharmacokinetics, and clinical activity. Expert Opin Drug Metab Toxicol. 2012 May;8(5):623-33. PMID: 22512706.

Fei HR, Chen G, Wang JM, et al. Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation. Cytotechnology. 2010 Oct;62(5):449-60. PMID: 20842425.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T291321

    Thiamine Mononitrate

    Vitamin B1

    ≥98%
  • T0140

    TAK-632

    RAF inhibitor.

    ≥99%
  • I0416

    Iberin

    Isothiocyanate found in cruciferous vegetables,...

    ≥97%
  • G0175

    Gastric Inhibitory Peptide, human

    Endogenous peptide hormone, somatostatin analog...

    ≥95%
  • D1995

    Dexrazoxane Hydrochloride

    Iron chelator.

    ≥98%
  • S1846

    Selumetinib

    MEK1/2 inhibitor.

    ≥99%
  • U6957

    Urotensin I

    Endogenous peptide, involved in stress signalin...

    ≥95%
  • A4849

    Amyloid-β (25-35)

    Endogenous APP peptide cleavage product, primar...

    ≥95%
  • D3449

    Dimethoxycurcumin

    Curcumin derivative.

    ≥98%
  • N5767

    Norethindrone

    Steroid hormone, contraceptive; PR agonist.

    ≥98%
  • A488240

    AMG-337

    Selective inhibitor of c-Met.

    ≥99%
  • M2408

    MGCD-265 Analog

    MET inhibitor.

    ≥98%
  • R2710

    Recombinant Multi-epitope Chimeric HCV Antigen

    Recombinant Multi-epitope Chimeric HCV antigen....

    ≥95%
  • D5753

    Donepezil Hydrochloride

    GSK3 and AChE inhibitor, potential σ1 agonist....

    ≥98%
  • S824766

    Sutezolid

    Bactericidal.

    ≥98%
  • SB5778

    Snake venom – Bothrops neuwiedi diporous

    Snake venom found in Bothrops neuwiedi diporus;...

    ≥98%
  • M1687

    Mevinolin

    Statin, naturally produced by mushrooms; HMG-Co...

    ≥97%
  • T0394

    (+)-Taxifolin

    Catechol-type flavonoid; fatty acid synthesis i...

    ≥98%
  • A064766

    ABT 639

    T-type calcium channel blocker

    ≥99%
  • V0244

    Valganciclovir Hydrochloride

    Nucleoside (deoxyguanosine) analog, ganciclovir...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only