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PF-06873600

PF-06873600

Product ID P200600
Cas No. 2185857-97-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $159.90 In stock
5 mg $468.60 In stock
10 mg $882.00 In stock
25 mg $1,819.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

PF-06873600 is a selective inhibitor of CDK2/4/6 in multiple in vivo tumor models.

Product Info

Cas No.

2185857-97-8

Purity

≥98%

Formula

C20H27F2N5O4S

Formula Wt.

471.52

IUPAC Name

6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrido[2,3-d]pyrimidin-7-one

Synonym

PF06873600, Ebvaciclib

Appearance

White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

P200600 Info Sheet PDF

References

Freeman-Cook K, Hoffman R, Miller N, et al. Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor. Cancer Cell. 2021 Oct 11;39(10):1404-1421. PMID: 34520734

Jeselsohn R, Schiff R, Grinshpun A. Restoring order at the cell cycle border: co-targeting CDK4/6 and CDK2. Cancer Cell. 2021 Oct 11;39(10):1302-1305. PMID: 34506738

Freeman-Cook K, Hoffman R, Behenna D, et al. Discovery of PF-06873600, a CDK2/4/6 inhibitor for the treatment of cancer. J Med Chem. 2021 Jul 8;64(13):9056-9077. PMID: 34110834

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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