Description
PF-06873600 is a selective inhibitor of CDK2/4/6 in multiple in vivo tumor models.
| Product Unit Size | Cost | Quantity | Stock | 
|---|
PF-06873600 is a selective inhibitor of CDK2/4/6 in multiple in vivo tumor models.
| Cas No. | 2185857-97-8 | 
|---|---|
| Purity | ≥98% | 
| Formula | C20H27F2N5O4S | 
| Formula Wt. | 471.52 | 
| IUPAC Name | 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrido[2,3-d]pyrimidin-7-one | 
| Synonym | PF06873600, Ebvaciclib | 
| Appearance | White powder | 
| Store Temp | -20°C | 
|---|---|
| Ship Temp | Ambient | 
| Info Sheet | 
|---|
Freeman-Cook K, Hoffman R, Miller N, et al. Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor. Cancer Cell. 2021 Oct 11;39(10):1404-1421. PMID: 34520734
Jeselsohn R, Schiff R, Grinshpun A. Restoring order at the cell cycle border: co-targeting CDK4/6 and CDK2. Cancer Cell. 2021 Oct 11;39(10):1302-1305. PMID: 34506738
Freeman-Cook K, Hoffman R, Behenna D, et al. Discovery of PF-06873600, a CDK2/4/6 inhibitor for the treatment of cancer. J Med Chem. 2021 Jul 8;64(13):9056-9077. PMID: 34110834
β-lactamase inhibitor.
Multikinase inhibitor.
Found in Aristolochia and Radix; potential PLA2...
Fermentation impurity
Arp2/3 inhibitor.
Synthetic steroid, contraceptive; PR and glucoc...
Curcumin derivative; DNMT1 and α-amylase inhib...
Found in Salvia; fatty acid synthase and AChE i...
Vitamin A derivative; RAR and RXR agonist.
BHA derivative; potential Ca2+ ATPase inhibitor...
Nitrosourea, DNA alkylator.
Polyphenol found in species of Solanum and Magn...
Tocopherol analog
Histamine H1 antagonist, FIASMA.
β-lactamase inhibitor.
Triterpene saponin found in Bupleurum.
Recombinant protein containing Treponema pallid...
EGFR2 inhibitor.
NSAID; PG synthetase inhibitor.
α-glucosidase inhibitor.