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PF-07321332

PF-07321332

Product ID P200002
Cas No. 2628280-40-8
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $99.80 In stock
25 mg $236.30 In stock
100 mg $472.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

PF-07321332 (nirmatrelvir) is a protease inhibitor. It is considered a broad-spectrum inhibitor for coronaviruses.

Product Info

Cas No.

2628280-40-8

Purity

≥99%

Formula

C23H32F3N5O4

Formula Wt.

499.5

Chemical Name

(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide

IUPAC Name

(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide

Synonym

Nirmatrelvir; 7R9A5P7H32; Paxlovid; PF07321332

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P200002 MSDS PDF

Info Sheet

P200002 Info Sheet PDF

References

Zhao Z, Zhu Q, Zhou X, et al. Structural basis for the inhibition of SARS-CoV-2 Mpro D48N mutant by shikonin and PF-07321332. Viruses. 2023 Dec 30;16(1):65. PMID: 38257765.

J A Mótyán, M Mahdi, G. Hoffka, et.al. Potential Resistance of SARS-CoV-2 Main Protease (Mpro) against Protease Inhibitors: Lessons Learned from HIV-1 Protease. Int J Mol Sci. 2022 Mar 23;23(7):3507.

S. Ullrich, K. B. Ekanayake, G. Otting, etl al. Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir. Bioorg Med Chem Lett 2022 Apr 15;62:128629. PMID: 35182772.

J. Li, C. Lin, X. Zhou, et al. Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332. J Virol. 2022 Apr 7;e0201321. doi: 10.1128/jvi.02013-21.

Custom Order

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  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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