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Phenylbutyrate Sodium

Phenylbutyrate Sodium

Product ID P2815
Cas No. 1716-12-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $86.80 In stock
5 g $282.20 In stock
25 g $1,125.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Phenylbutyrate is an inhibitor of histone deacetylase (HDAC) that exhibits neuroprotective and anticancer chemotherapeutic activities. In cellular and animal models of pancreatic cancer, phenylbutyrate inhibits cellular proliferation and tumor growth. This compound is clinically used to treat urea cycle disorders, as it allows excretion of excess nitrogen waste. In animal models of Alzheimer’s disease, phenylbutyrate prevents neuronal loss and normalizes brain pathology.

Product Info

Cas No.

1716-12-7

Purity

≥98%

Formula

C10H11O2Na

Formula Wt.

186.18

Chemical Name

Benzenebutanoic acid, sodium salt

IUPAC Name

sodium;4-phenylbutanoate

Synonym

Buphenyl, Sodium 4-phenylbutyrate, Tributyrate

Melting Point

214-220°C

Solubility

Soluble in water, ethanol, DMSO.

Appearance

White crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P2815 MSDS PDF

Info Sheet

P2815 Info Sheet PDF

Brochures

Epigenetic Modifiers Booklet

References

Jiang Z, He Q, Wezeman J, et al. A cocktail of rapamycin, acarbose, and phenylbutyrate prevents age-related cognitive decline in mice by targeting multiple pathways. Geroscience. 2024 Oct;46(5):4855-4868. PMID: 38755466.

Cuadrado-Tejedor M, Ricobaraza AL, Torrijo R, et al. Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model. Curr Pharm Des. 2013;19(28):5076-84. PMID: 23448463.

Dovzhanskiy DI, Hartwig W, Lázár NG, et al. Growth inhibition of pancreatic cancer by experimental treatment with 4-phenylbutyrate is associated with increased expression of Connexin 43. Oncol Res. 2012;20(2-3):103-11. PMID: 23193916.

Iannitti T, Palmieri B. Clinical and experimental applications of sodium phenylbutyrate. Drugs R D. 2011 Sep 1;11(3):227-49. PMID: 21902286.

Batshaw ML, MacArthur RB, Tuchman M. Alternative pathway therapy for urea cycle disorders: twenty years later. J Pediatr. 2001 Jan;138(1 Suppl):S46-54; Erratum in: J Pediatr 2002 Apr;140(4):490. PMID: 11148549.

Custom Order

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