• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Phenylhexyl Isothiocyanate

Phenylhexyl Isothiocyanate

Product ID P2922
Cas No. 133920-06-6
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $112.60 In stock
100 mg $206.00 In stock
250 mg $412.50 In stock
500 mg $619.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Isothiocyanates are compounds typically found in plants of the Brassicaceae family, including broccoli, cabbage, and radish. Isothiocyanates are best known for their antioxidative, anticancer chemotherapeutic, chemopreventive, anti-angiogenic, and antibiotic properties. In vitro, phenhexyl isothiocyanate (PHITC) increases caspase 3 activity and cleavage of poly(ADP)-ribose polymerase (PARP), inducing caspase-mediated apoptosis in cellular models. This compound decreases oxidation of carcinogen NNK and increases activity of NADPH:quinone oxidoreductase and glutathione S-transferase in vitro and in vivo. PHITC inhibits histone deacetylase (HDAC) activity, IL-6 receptor production, and VEGF expression; it also induces mitochondrial membrane depolarization and apoptosis in myeloma cells. In leukemia cells, PHITC inhibits expression of cyclin and increases expression of cyclin dependent kinase (CDK) inhibitors, inducing apoptosis and inhibiting growth of xenografts of these cells in animals.

Product Info

Cas No.

133920-06-6

Purity

≥98%

Formula

C13H17NS

Formula Wt.

219.35

IUPAC Name

6-isothiocyanatohexylbenzene

Synonym

6-Phenylhexyl isothiocyanate, PHITC

Solubility

Soluble in oraganic solvents.

Appearance

Clear colorless liquid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P2922 MSDS PDF

Info Sheet

P2922 Info Sheet PDF

References

Lu Q, Lin X, Feng J, et al. Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways. J Hematol Oncol. 2008 Jun 9;1:6. PMID: 18577263.

Lu L, Liu D, Ma X, et al. The phenylhexyl isothiocyanate induces apoptosis and inhibits leukemia cell growth in vivo. Oncol Rep. 2006 Dec;16(6):1363-7. PMID: 17089062.

Morse MA, Eklind KI, Hecht SS, et al. Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. Cancer Res. 1991 Apr 1;51(7):1846-50. PMID: 2004368.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C9809

    Cyclopiazonic Acid

    SERCA inhibitor.

    ≥98%, TLC
  • F4583

    Flupirtine Maleate

    Kv7 K+ channel activator, NMDA antagonist, GABA...

    ≥98%
  • A971334

    Azilsartan

    Sartan

    ≥98%
  • C8070

    Curcumin, high purity

    Active compound found in turmeric; MST1 activat...

    ≥98%
  • B1992

    Bexarotene

    RXR agonist.

    ≥98%
  • H9714

    L-5-Hydroxytryptophan

    Endogenous amino acid, precursor of 5-HT and me...

    ≥98%
  • C3260

    Ciprofibrate

    Fibrate; PPARα agonist.

    ≥98%
  • E5358

    Enoxacin

    Fluoroquinolone; vacuolar H+ ATPase, topoisomer...

    ≥98%
  • S0381

    Sauvagine

    CRF-related peptide found in amphibians.

    ≥98%
  • D1776

    Desmopressin

    Synthetic vasopressin derivative; V2R agonist.<...

    ≥95%
  • D564088

    10-Acetyl Docetaxel

    Docetaxel impurity

    ≥98%
  • T9946

    Tylosin Phosphate

    Macrolide; peptidyl transferase inhibitor, prot...

    ≥90%
  • C446176

    Clemastine Fumarate

    Antihistamine with potential neuroprotective ac...

    ≥99%
  • M9645

    Myelin Oligodendrocyte Glycoprotein (35-55), rat

    Oligodendrocyte antigen used to induce EAE.

    ≥95%
  • T1004

    Paclitaxel Oxetane Ring-Opened 3-Acetyl 4-Benzoyl Impurity

    Synthesis impurity

    ≥92%
  • N1983

    Neuropeptide Y (3-36), human

    Endogenous peptide neurotransmitter, involved i...

    ≥95%
  • S5200

    SNA 1

    Sialic-acid sensing lectin.

    ≥98%
  • C1629

    Cefoperazone Acid

    β-lactam cephalosporin; penicillin binding pro...

    ≥98%
  • P1634

    Peimine

    Steroidal alkaloid found in Fritillaria; TRPV1 ...

    ≥98%
  • R0243

    Raloxifene Hydrochloride

    SERM.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only