LKT Labs

Biochemicals for Life Science Research

Physcion

Physcion

Product ID P2995
Cas No. 521-61-9
Purity ≥96%
Product Unit SizeCostQuantityStock
10 mg $189.00 In stock
25 mg $310.00 In stock
100 mg $775.00 In stock
Bulk Quote

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Description

Physcion is an anthraquinone originally found in several plant sources, including Microsporum, Psorospermum, Rhamnus, and Rheum. Physcion exhibits anticancer, antibiotic, and anti-inflammatory activities. In cervical carcinoma cells, physcion induces apoptosis by downregulating expression of Bcl-2 and upregulating expression of Bax and activation of caspase 3. Physcion also exhibits antibacterial activity against Staphylococcus, Pseudomonas, and Escherichia, as well as antifungal activity against Candida and Aspergillus. In animal models, physcion inhibits iNOS expression and decreases edema volume.

Product Info

Cas No.

521-61-9
Purity

≥96%
Formula

C16H12O5
Formula Wt.

284.26
Chemical Name

1,8-Dihydroxy-3-methoxy-6-methylanthraquinone
IUPAC Name

1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione
Synonym

Parietin, Physcione, Rheochrysidin.
Melting Point

203-207C
Solubility

Insoluble in water, slightly soluble in cold alcohol, soluble in boiling alcohol, soluble in benzene, chloroform, ether, acetone, acetic acid, sodium hydroxide and hot sodium carbonate solution, and very slightly soluble in petroleum ether.
Appearance

Yellow powder

Shipping and Storage

Store Temp

4°C
Ship Temp

ambient

Downloads

MSDS

P2995 MSDS PDF
Info Sheet

P2995 Info Sheet PDF

References

Wijesekara I, Zhang C, Van Ta Q, et al. Physcion from marine-derived fungus Microsporum sp. induces apoptosis in human cervical carcinoma HeLa cells. Microbiol Res. 2014 Apr;169(4):255-61. PMID: 24071573.

Locatelli M, Epifano F, Genovese S, et al. Anthraquinone profile, antioxidant and antimicrobial properties of bark extracts of Rhamnus catharticus and R. orbiculatus. Nat Prod Commun. 2011 Sep;6(9):1275-80. PMID: 21941897.

Ghosh S, Das Sarma M, Patra A, et al. Anti-inflammatory and anticancer compounds isolated from Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn. J Pharm Pharmacol. 2010 Sep;62(9):1158-66. PMID: 20796195.

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