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Pifithrin-alpha is a small molecule inhibitor of p53 shown to prevent neuronal death induced by DNA damage. Pifithrin-alpha has also been found to interfere in heat shock and glucocorticoid receptor signaling pathways. Both in vivo and in vitro pifithrin-alpha inhibited firefly luciferase activity.
| Cas No. | 63208-82-2 |
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| Purity | ≥98% |
| Formula | C16H18N2OS • HBr |
| Formula Wt. | 367.31 |
| IUPAC Name | 2-(2-Imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3(2H)-yl)-1-(4-methylphenyl)ethanone hydrobromide (1:1) |
| Synonym | Pifithrin-alpha.HBr |
| Solubility | Soluble in DMSO to 100 mM |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Komarova EA, Nenanov N, Komarov PG, et al. p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways. J Biol Chem. 2003 May 2;278(18):15465-15468. PMID: 12637507.
Rocha S, Campbell KJ, Roche KC, et al. The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro. BMC Mol Biol. 2003 Sep 11;4:9. PMID: 12967348.
Kanno S, Kurachi K, Tomizawa A, et al. Pifithrin-alpha has a p53-independent cytoprotective effect on docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma HepG2 cells. Toxicl Lett. 2015 Jan 22, 232(2):393-402. PMID: 25448278.
Murphy PJ, Galigniana MD, Morishima Y, et al. Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation. J Biol Chem. 2004 Jul 16;279(29):30195-30201. PMID: 15145929.