LKT Labs

Biochemicals for Life Science Research

Pimecrolimus

Pimecrolimus

Product ID P3348
Cas No. 137071-32-0
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $60.10 In stock
5 mg $112.60 In stock
25 mg $375.60 In stock
Bulk Quote

Quicklinks

Description

Pimecrolimus is a calcineurin inhibitor that exhibits immunosuppressive, anti-inflammatory, and antinociceptive activities. Pimecrolimus prevents calcineurin from dephosphorylating nuclear factor of activated T cells (NF-AT), inhibiting T cell signaling; this inhibition of T cell signaling also prevents release of pro-inflammatory cytokines. Pimecrolimus is clinically used to treat inflammatory skin diseases such as cutaneous lupus erythematosus and contact dermatitis. This compound also displays some antinociceptive properties and may desensitize transient receptor potential vanilloid receptor 1 (TRPV1) channels in skin sensory neurons.

Product Info

Cas No.

137071-32-0
Purity

≥99%
Formula

C43H66ClNO11
Formula Wt.

810.45
Chemical Name

33-epi-chloro-33-desoxyascomycin
IUPAC Name

(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-12-[(E)-1-[(1R,3R,4S)-4-chloro-3-methoxycyclohexyl]prop-1-en-2-yl]-17-ethyl-1,14-dihydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
Synonym

33-epi-chloro-33-desoxyascomycin; Elidel; SDZ-ASM 981; SDZ ASM 981; SDZ-ASM-981; Picrolimus; ASM981; ASM-981; ASM 981
Solubility

Soluble in DMSO (25 mg/mL). Soluble in ethanol (25 mg/mL). Soluble in chloroform, methanol.
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P3348 MSDS PDF
Info Sheet

P3348 Info Sheet PDF

References

Xie ZQ, Lan YZ. Effectiveness of pimecrolimus cream for women patients with sensitive skin and its underlying mechanism. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012 Aug;34(4):375-8. PMID: 22954121.

Lampropoulos CE, D'Cruz DP. Topical calcineurin inhibitors in systemic lupus erythematosus. Ther Clin Risk Manag. 2010 Apr 15;6:95-101. PMID: 20421909.

Hultsch T, Kapp A, Spergel J. Immunomodulation and safety of topical calcineurin inhibitors for the treatment of atopic dermatitis. Dermatology. 2005;211(2):174-87. Review. Erratum in: Dermatology. 2005;211(3):292. PMID: 16088174.

Lipozencić J. Pimecrolimus--a safe and effective local immunomodulator in the treatment of inflammatory skin diseases. Acta Dermatovenerol Croat. 2005;13(1):63-9. PMID: 15788149.

Gupta AK, Chow M. Pimecrolimus: a review. J Eur Acad Dermatol Venereol. 2003 Sep;17(5):493-503. PMID: 12941081.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G1975

    Gestrinone

    Synthetic steroid hormone; AR agonist, ER and P...

    ≥98%
  • P4492

    PLX4720

    V600E B-Raf inhibitor.

    ≥98%
  • A2054

    Aflatoxin M2

    Mycotoxin produced by species of Aspergillus; D...

    ≥98%
  • B0110

    Baclofen

    GABA derivative; GABA-B agonist.

    ≥98%
  • D324090

    Diclofenac Impurity C

    Impurity of diclofenac

    ≥98%
  • M8007

    Mubritinib, Free Base

    EGFR2 inhibitor.

    ≥99%
  • G4796

    Glycerol Monolaurate

    Surfactant found in coconut oil.

    ≥98%
  • C9660

    Cypermethrin

    Synthetic type II pyrethroid insecticide; prote...

    ≥95%
  • C3374

    Cisplatin

    Pt-based DNA cross-linker.

    ≥99%
  • A7669

    A-type Natriuretic Peptide (1-28), rat

    Endogenous cardiomodulatory peptide; NPR-A agon...

    ≥95%
  • E7377

    Estriol

    Endogenous steroid hormone, estradiol metabolit...

    ≥97%
  • K0117

    Kaempferol

    Flavonol found in various plant sources.

    ≥98%
  • R5700

    Ro 61-8048

    Kynurenine 3-hydroxylase inhibitor.

    ≥99%
  • B5000

    BMS-911543

    JAK2 inhibitor.

    ≥99%
  • F3206

    Fibrinolysis Inhibiting Factor

    Peptide; fibrinolysis inhibitor.

    ≥98%
  • R0351

    Ramoplanin

    Peptide; peptidoglycan inhibitor.

    ≥90%
  • D0005

    Dabrafenib Mesylate

    B-Raf and c-Raf inhibitor.

    ≥98%
  • M1622

    Mefenamic Acid

    NSAID; GABA-A potentiator, COX-1/2 inhibitor.

    ≥98%
  • C9677

    Cyclocytidine Hydrochloride

    Pyrimidine nucleoside analog; DNA synthesis inh...

    ≥98%
  • T0099

    10-Deacetylbaccatin-III

    Diterpene found in Taxus.

    ≥98%