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Pipemidic Acid

Pipemidic Acid

Product ID P3461
Cas No. 51940-44-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $52.50 In stock
10 g $89.70 In stock
100 g $561.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
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  • References
  • Description
  • Product Info
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Description

Pipemidic acid is a pyridopyrimidine antibiotic that inhibits bacterial DNA gyrase; it exhibits antibacterial activity. Pipemidic acid also inhibits ATP-sensitive K+ channels, inducing insulin release in vitro, suggesting potential a potential link to hypoglycemia. High doses of pipemidic acid induce cartilage toxicity (arthropathy) in neonatal mice.

Product Info

Cas No.

51940-44-4

Purity

≥98%

Formula

C14H17N5O3

Formula Wt.

303.32

Chemical Name

8-ethyl-5-oxo-2-piperazin-1-ylpyrido[2,3-d]pyrimidine-6-carboxylic acid

IUPAC Name

8-ethyl-5-oxo-2-piperazin-1-ylpyrido[2,3-d]pyrimidine-6-carboxylic acid

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P3461 MSDS PDF

Info Sheet

P3461 Info Sheet PDF

References

Aubry A, Pan XS, Fisher LM, et al. Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity. Antimicrob Agents Chemother. 2004 Apr;48(4):1281-8. PMID: 15047530.

Maeda N, Tamagawa T, Niki I, et al. Increase in insulin release from rat pancreatic islets by quinolone antibiotics. Br J Pharmacol. 1996 Jan;117(2):372-6. PMID: 8789393.

Linseman DA, Hampton LA, Branstetter DG. Quinolone-induced arthropathy in the neonatal mouse. Morphological analysis of articular lesions produced by pipemidic acid and ciprofloxacin. Fundam Appl Toxicol. 1995 Nov;28(1):59-64. PMID: 8566484.

Aoyama H, Sato K, Fujii T, et al. Purification of Citrobacter freundii DNA gyrase and inhibition by quinolones. Antimicrob Agents Chemother. 1988 Jan;32(1):104-9. PMID: 2831810.

Custom Order

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