LKT Labs

Biochemicals for Life Science Research

Pituitary Adenylate Cyclase-activating Polypeptide (1-27), human, sheep, rat

Pituitary Adenylate Cyclase-activating Polypeptide (1-27), human, sheep, rat

Product ID P0005
Cas No. 127317-03-7
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $136.50 In stock
1 mg $283.50 Please Inquire
2.5 mg $556.50 In stock
Bulk Quote

Quicklinks

Description

Pituitary adenylate cyclase-activating polypeptide (PACAP) is an endogenous peptide that stimulates cAMP production in the anterior pituitary. PACAP and PACAP-related peptide (PRP) regulate immune function and display increases in expression when hosts are challenged with bacterial pathogens. PACAP and PRP also control expression of reproductive hormones such as follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Additionally, PACAP and PRP bind the PAC1 receptor and VPAC1/2 receptors. PACAP itself inhibits K+ amplitude of delayed rectifier K+ channels, exhibiting anti-apoptotic activity in cerebellar granule cells.

Product Info

Cas No.

127317-03-7
Purity

≥95%
Formula

C142H224N40O39S
Formula Wt.

3147.68
Synonym

PACAP (1-27)
Solubility

Soluble in water (1 mg/mL).

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

P0005 MSDS PDF
Info Sheet

P0005 Info Sheet PDF

References

Nam BH, Moon JY, Kim YO, et al. Structural and functional characterization of pituitary adenylyl cyclase-activating polypeptide (PACAP)/PACAP-related peptide (PRP) and its receptor in olive flounder (Paralichthys olivaceus). Comp Biochem Physiol B Biochem Mol Biol. 2013 Jan;164(1):18-28. PMID: 23026070.

Tam JK, Lee LT, Cheng CH, et al. Discovery of a new reproductive hormone in teleosts: pituitary adenylate cyclase-activating polypeptide-related peptide (PRP). Gen Comp Endocrinol. 2011 Sep 15;173(3):405-10. PMID: 21703272.

Vaudry D, Falluel-Morel A, Bourgault S, et al. Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacol Rev. 2009 Sep;61(3):283-357. PMID: 19805477.

Mei YA, Vaudry D, Basille M, et al. PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway: evidence for the involvement of I k in the anti-apoptotic action of PACAP. Eur J Neurosci. 2004 Mar;19(6):1446-58. PMID: 15066141.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D4873

    Meso-2,3-dimercaptosuccinic Acid

    Organosulfur, chelating agent.

    ≥98%
  • P0006

    Pituitary Adenylate Cyclase-activating Polypeptide (1-38), human, sheep, rat

    Endogenous peptide, involved in paracrine and a...

    ≥95%
  • L1735

    Levitide

    Antimicrobial peptide found in amphibians.

    ≥95%
  • E8401

    Evacetrapib

    Cholesterol ester transfer protein inhibitor.

    ≥98%
  • D3447

    Diltiazem Hydrochloride

    Benzothiazepine; L-type Ca2+ channel blocker, p...

    ≥98%
  • C1633

    Cefotaxime Sodium

    β-lactam cephalosporin; penicillin binding pro...

    ≥96%
  • A4441

    Allicin, aqueous solution

    Organosulfur found in garlic; Kir K+ channel ac...

    ≥98%
  • P3469

    Pirfenidone

    Collagen synthesis inhibitor.

    ≥98%
  • B165121

    Bedaquiline Fumarate

    Bactericidal

    ≥98%
  • N0262

    Naphazoline Hydrochloride

    α1-adrenergic agonist.

    ≥97%
  • S0224

    SAG

    Smoothened agonist.

    ≥98%
  • U6859

    Urocortin III, human

    Endogenous peptide, involved in stress signalin...

    ≥95%
  • T6803

    Trandolapril

    ACE inhibitor.

    ≥98%
  • V0376

    Vatalanib Dihydrochloride

    VEGFR inhibitor.

    ≥98%
  • Z0146

    Z-Ala-Ala-Leu-pNA

    Proteinase subtrate.

    ≥95%
  • W0269

    (±)-Warfarin

    Coumarin; VKORC1 inhibitor.

    ≥98%
  • D1757

    L-Deoxyalliin

    Organosulfur found in garlic.

    ≥98%
  • C3477

    Citalopram Hydrobromide

    SERT inhibitor.

    ≥98%
  • M4454

    MLN-4924

    Nedd8-activating enzyme inhibitor.

    ≥99%
  • P1852

    Penicillin G procaine

    Hydrophobic β-lactam; penicillin binding prote...

    ≥98%