• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Plasminogen Activator Inhibitor 1

Plasminogen Activator Inhibitor 1

Product ID P4403
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $81.70 In stock
1 mg $138.90 In stock
2.5 mg $245.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Plasminogen activator inhibitor 1 (PAI-1) is a peptide protease inhibitor that exhibits proliferation-enhancing activity in cancer models. PAI-1 is produced by thrombin activation of protease-activated receptor 1 (PAR1) and is clinically used as a biomarker for heart disease. PAI-1 increases cell proliferation and tumor size of HeLa xenografts in some models and may be over-expressed in cancerous tissue. In other animal models of cancer, PAI-1 exhibits anti-apoptotic activity through a mechanism that involved activation of plasmin and inhibition of Fas/FasL signaling. PAI-1 also displays pro-fibrotic characteristics and plays a role in type 1 diabetic osteoporosis; it promotes proliferation of pulmonary fibroblasts, enhances their transition to myofibroblasts, and increases collagen synthesis and activation of ERK and Akt.

Product Info

Purity

≥95%

Formula

C27H47N9O9S

Formula Wt.

673.79

Synonym

PAI-1

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P4403 MSDS PDF

Info Sheet

P4403 Info Sheet PDF

References

Gomes Giacoia E, Miyake M, Lawton A, et al. PAI-1 Leads to G1-phase Cell Cycle Progression through Cyclin D3/CDK4/6 Up-regulation. Mol Cancer Res. 2014 Jan 24. [Epub ahead of print]. PMID: 24464915.

Tamura Y, Kawao N, Okada K, et al. Plasminogen activator inhibitor-1 is involved in streptozotocin-induced bone loss in female mice. Diabetes. 2013 Sep;62(9):3170-9. PMID: 23715621.

Zhang YP, Wang WL, Liu J, et al. Plasminogen activator inhibitor-1 promotes the proliferation and inhibits the apoptosis of pulmonary fibroblasts by Ca(2+) signaling. Thromb Res. 2013 Jan;131(1):64-71. PMID: 23021499.

Fang H, Placencio VR, DeClerck YA. Protumorigenic activity of plasminogen activator inhibitor-1 through an antiapoptotic function. J Natl Cancer Inst. 2012 Oct 3;104(19):1470-84. PMID: 22984202.

McEachron TA, Church FC, Mackman N. Regulation of thrombin-induced plasminogen activator inhibitor-1 in 4T1 murine breast cancer cells. Blood Coagul Fibrinolysis. 2011 Oct;22(7):576-82. PMID: 21799402.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A0777

    ABT-263

    BH3 mimetic; Bcl-2 and Bcl-xl inhibitor.

    ≥99%
  • S2792

    SGX-523

    MET inhibitor.

    ≥98%
  • E6880

    Erucin

    Isothiocyanate found in cruciferous vegetables,...

    ≥98%
  • F4532

    Flibanserin

    5-HT1A agonist, 5-HT2A antagonist.

    ≥97%
  • F0275

    Fasudil Hydrochloride

    ROCK inhibitor.

    ≥98%
  • L1852

    Lenalidomide

    Thalidomide derivative; cereblon and TNF-α inh...

    ≥98%
  • P2859

    Phosphate Acceptor Peptide

    PKC and S6 kinase substrate.

    ≥95%
  • G4535

    Glimepiride

    Sulfonylurea; ATP-sensitive K+ channel blocker....

    ≥98%
  • P3465

    Piperine

    Alkaloid found in black and long peppers; TRPV1...

    ≥95%
  • A2400

    AG-1024

    Tyrphostin; IGF-1R inhibitor.

    ≥98%
  • D564090

    7-epi-Docetaxel

    Docetaxel impurity

    ≥95%
  • A9818

    Azelastine Hydrochloride

    TRPV1 agonist, histamine H1 antagonist.

    ≥98%
  • A9834

    Azithromycin Dihydrate

    Azalide macrolide; protein translation inhibito...

    ≥98%
  • T1012

    13-TES-Baccatin III

    Synthesis impurity

    ≥98%
  • B3300

    BI-6727

    PLK1 inhibitor.

    ≥99%
  • P0144

    Paliperidone

    D2 and 5-HT2A antagonist.

    ≥97%
  • T564093

    (+)-δ-Tocopherol

    Vitamin E component

    ≥98%
  • B030960

    BAY-1082439

    PI3K inhibitor.

    ≥98%
  • A0966

    Adrenocorticotropic Hormone (1-16), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • F6803

    FRAX486

    PAK inhibitor.Smo inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only