• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Plumbagin

Plumbagin

Product ID P4780
Cas No. 481-42-5
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $54.70 Please Inquire
250 mg $69.20 In stock
1 g $178.60 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Plumbagin is a naphthoquinone found in a variety of Plumbago species; it exhibits anticancer, anti-inflammatory, antibacterial, and anti-diabetic activities. In cellular models of cancer, plumbagin increases reactive oxygen species production, increases the Bax/Bcl-2 ratio, inhibits activation of NF-κB, and increases caspase activity, inducing apoptosis. In an in vivo model of ulcerative colitis, plumbagin decreases levels of pro-inflammatory cytokines such as TNF-α, IL-17, and IFN-γ, and also decreases colonic monocyte aggregation. This compound also inhibits the assembly and GTPase activity of FtsZ, which plays a significant role in bacterial cell division, inhibiting proliferation in vitro. Additionally, plumbagin inhibits TGF-β1-induced fibronectin and collagen IV expression in vitro and reverses diabetic nephropathy via alterations in Nox4 signaling in diabetic mice.

Product Info

Cas No.

481-42-5

Purity

≥98%

Formula

C11H8O3

Formula Wt.

188.18

Chemical Name

5-hydroxy-2-methylnaphthalene-1,4-dione

IUPAC Name

5-hydroxy-2-methylnaphthalene-1,4-dione

Synonym

Plumbaein

Appearance

Orange Crystals

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P4780 MSDS PDF

Info Sheet

P4780 Info Sheet PDF

References

Sagar S, Esau L, Moosa B, et al. Cytotoxicity and Apoptosis Induced by a Plumbagin Derivative in Estrogen Positive MCF-7 Breast Cancer Cells. Anticancer Agents Med Chem. 2013 Oct 21. [Epub ahead of print]. PMID: 24164046.

Yong R, Chen XM, Shen S, et al. Plumbagin ameliorates diabetic nephropathy via interruption of pathways that include NOX4 signalling. PLoS One. 2013 Aug 26;8(8):e73428. PMID: 23991195.

Qiu JX, He YQ, Wang Y, et al. Plumbagin induces the apoptosis of human tongue carcinoma cells through the mitochondria-mediated pathway. Med Sci Monit Basic Res. 2013 Aug 28;19:228-36. PMID: 23982457.

Bhattacharya A, Jindal B, Singh P, et al. Plumbagin inhibits cytokinesis in Bacillus subtilis by inhibiting FtsZ assembly--a mechanistic study of its antibacterial activity. FEBS J. 2013 Sep;280(18):4585-99. PMID: 23841620.

Pile JE, Navalta JW, Davis CD, et al. Interventional effects of plumbagin on experimental ulcerative colitis in mice. J Nat Prod. 2013 Jun 28;76(6):1001-6. PMID: 23742275.

Xu TP, Shen H, Liu LX, et al. Plumbagin from Plumbago Zeylanica L induces apoptosis in human non-small cell lung cancer cell lines through NF-κB inactivation. Asian Pac J Cancer Prev. 2013;14(4):2325-31. PMID: 23725135.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R5774

    Roscovitine

    CDK inhibitor, L-type Ca2+ channel blocker.

    ≥98%
  • U6873

    Ursodeoxycholic Acid

    Endogenous secondary bile acid.

    ≥98%
  • T1674

    Terbutaline Sulfate

    β2-adrenergic agonist, potential ENaC activato...

    ≥98%
  • V0146

    Valsartan

    AT1 inhibitor.

    ≥98%
  • T165133

    Tedizolid Phosphate

    Effective against gram-positive pathogens

    ≥98%
  • F4584

    Fluphenazine Hydrochloride

    Piperazine; FIASMA, D2 antagonist, hERG K+ chan...

    ≥97%
  • S7618

    StemRegenin 1 Hydrochloride

    AhR antagonist.

    ≥98%
  • T1675

    Teriparatide Acetate

    Synthetic peptide hormone, PTH analog; PTH1R ag...

    ≥95%
  • T2402

    TG100-115

    p110δ and p110γ PI3K inhibitor.

    ≥98%
  • S0170

    Sarafloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥95%
  • V182705

    Verubecestat

    BACE1 inhibitor

    ≥98%
  • C9708

    CYC-116

    AurKB/C inhibitor.

    ≥98%
  • V174459

    Velpatasvir

    Inhibits NS5A

    ≥99%
  • C5968

    Cordycepin

    Nucleoside (deoxyadenosine) analog found in Co...

    ≥99%
  • C0168

    Canthaxanthin

    Carotenoid terpene pigment found in various pla...

    ≥9% (product contains stabilizers)
  • F5968

    Foretinib

    ROS1, MET, Ron, Axl, TIE-2, VEGFR2 inhibitor.

    ≥98%
  • S1971

    Sertraline Hydrochloride

    FIASMA, SERT and DAT inhibitor, α1-adrenergic ...

    ≥98%
  • A5161

    Ampiroxicam

    Piroxicam prodrug, NSAID; COX-1/2 inhibitor.

    ≥98%
  • N0161

    β-Naphthoflavone

    AhR agonist.

    ≥98%
  • L1628

    Ac-LEHD-pNa

    Caspase 9 substrate.

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only